Publications
Detailed Information
Shank 2 expression coincides with neuronal differentiation in the developing retina
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jeong Hun | - |
dc.contributor.author | Kim, Jin Hyoung | - |
dc.contributor.author | Yang, Esther | - |
dc.contributor.author | Park, Jae Hwan | - |
dc.contributor.author | Yu, Young Suk | - |
dc.contributor.author | Kim, Kyu Won | - |
dc.date.accessioned | 2010-07-05 | - |
dc.date.available | 2010-07-05 | - |
dc.date.issued | 2009-03-21 | - |
dc.identifier.citation | Exp Mol Med. 2009;41(4):236-242 | en |
dc.identifier.issn | 1226-3613 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19299912 | - |
dc.identifier.uri | http://synapse.koreamed.org/Synapse/Data/PDFData/0061EMM/emm-41-236.pdf | - |
dc.identifier.uri | https://hdl.handle.net/10371/68219 | - |
dc.description.abstract | The retinal activity for vision requires a precise synaptic connectivity. Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. However, the correlation of Shank 2 expression with neuronal differentiation in the developing retina remains to be elucidated regardless of previous evidences of Shank 2 expression in retina. Herein, we demonstrated that with progression of development, Shank 2 is initially detected in the inner plexiform layer at P2, and then intensively detected in inner plexiform layer, outer plexiform layer, and ganglion cell layer at P14, which was closely colocalized to the neurofilament expression. Shank 2 was, however, not colocalized with glial fibrillary acidic protein. Shank 2 expression was increased in the differentiated retinoblastoma cells, which was mediated by ERK 1/2 activation. Moreover, Shank 2 expression was colocalized with neurofilament at the dendritic region of cells. In conclusion, our data suggests that Shank 2 is expressed in the neurons of the developing retina and could play a critical role in the neuronal differentiation of the developing retina. | en |
dc.description.sponsorship | This work was supported by KT& G research grant
(06-2006-113-9) for neonatal diseases from the Seoul National University Children's Hospital and by R01-2004- 000-10212-0 from the Basic Research Program of the Korea Science and Engineering Foundation. | en |
dc.language.iso | en | en |
dc.publisher | Korean Society of Medical Biochemistry | en |
dc.subject | Adaptor Proteins, Signal Transducing/genetics/*metabolism | en |
dc.subject | Animals | en |
dc.subject | Astrocytes/cytology/metabolism | en |
dc.subject | Cell Differentiation/*physiology | en |
dc.subject | Enzyme Activation | en |
dc.subject | Extracellular Signal-Regulated MAP Kinases/metabolism | en |
dc.subject | Mice | en |
dc.subject | Mice, Inbred C57BL | en |
dc.subject | Nerve Tissue Proteins/genetics/*metabolism | en |
dc.subject | Neurofilament Proteins/metabolism | en |
dc.subject | Neurons/cytology/*physiology | en |
dc.subject | Retinoblastoma/metabolism/pathology | en |
dc.subject | Gene Expression Regulation, Developmental | - |
dc.subject | Retina/cytology/growth & development/physiology | - |
dc.title | Shank 2 expression coincides with neuronal differentiation in the developing retina | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김정훈 | - |
dc.contributor.AlternativeAuthor | 김진형 | - |
dc.contributor.AlternativeAuthor | 양에스더 | - |
dc.contributor.AlternativeAuthor | 박재환 | - |
dc.contributor.AlternativeAuthor | 유영석 | - |
dc.contributor.AlternativeAuthor | 김규원 | - |
dc.identifier.doi | 10.3858/emm.2009.41.4.026 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.