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Histological differences in full-thickness vs. lamellar corneal pig-to-rabbit xenotransplantation

Cited 11 time in Web of Science Cited 14 time in Scopus
Authors
Oh, Joo Youn; Kim, Mee Kum; Ko, Jung Hwa; Lee, Hyun Ju; Park, Chung-Gyu; Kim, Sang Joon; Wee, Won Ryang; Lee, Jin Hak
Issue Date
2009-03-06
Publisher
Wiley-Blackwell
Citation
Vet Ophthalmol. 2009; 12(2): 78-82
Keywords
AnimalsCornea/cytology/pathologyCorneal Transplantation/methods/*veterinaryEosinophilsGraft RejectionLeukocytes, Mononuclear*Rabbits*SwineTransplantation, Heterologous/*veterinary
Abstract
To evaluate the differences in graft survival and histopathological characteristics between full-thickness and lamellar orthotopic corneal xenotransplantation in a pig-to-rabbit model, we orthotopically transplanted a full-thickness or the anterior half of a pig's cornea onto the OD of 16 rabbits. As a result, the median survival were 16.83 and 29.07 days for the full-thickness and lamellar xenografts, respectively (P = 0.0005). Histologically, the full-thickness corneal xenografts had massive infiltration by eosinophils, whereas the lamellar xenografts showed predominantly mononuclear infiltrates (P < 0.05). Given these preliminary findings, lamellar corneal xenografts in rabbits survived longer than the full-thickness xenografts and each type of graft demonstrated different rejection mechanisms.
ISSN
1463-5224 (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19261161

http://hdl.handle.net/10371/68243
DOI
https://doi.org/10.1111/j.1463-5224.2008.00680.x
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College of Medicine/School of Medicine (의과대학/대학원)Ophthalmology (안과학전공)Journal Papers (저널논문_안과학전공)
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