S-Space College of Medicine/School of Medicine (의과대학/대학원) Ophthalmology (안과학전공) Journal Papers (저널논문_안과학전공)
Histological differences in full-thickness vs. lamellar corneal pig-to-rabbit xenotransplantation
- Oh, Joo Youn; Kim, Mee Kum; Ko, Jung Hwa; Lee, Hyun Ju; Park, Chung-Gyu; Kim, Sang Joon; Wee, Won Ryang; Lee, Jin Hak
- Issue Date
- Vet Ophthalmol. 2009; 12(2): 78-82
- Animals; Cornea/cytology/pathology; Corneal Transplantation/methods/*veterinary; Eosinophils; Graft Rejection; Leukocytes, Mononuclear; *Rabbits; *Swine; Transplantation, Heterologous/*veterinary
- To evaluate the differences in graft survival and histopathological characteristics between full-thickness and lamellar orthotopic corneal xenotransplantation in a pig-to-rabbit model, we orthotopically transplanted a full-thickness or the anterior half of a pig's cornea onto the OD of 16 rabbits. As a result, the median survival were 16.83 and 29.07 days for the full-thickness and lamellar xenografts, respectively (P = 0.0005). Histologically, the full-thickness corneal xenografts had massive infiltration by eosinophils, whereas the lamellar xenografts showed predominantly mononuclear infiltrates (P < 0.05). Given these preliminary findings, lamellar corneal xenografts in rabbits survived longer than the full-thickness xenografts and each type of graft demonstrated different rejection mechanisms.
- 1463-5224 (Electronic)
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