S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Medicine (의학과) The Seoul Journal of Medicine The Seoul Journal of Medicine Vol. 24 No.3 (1983)
난소 과립막세포종의 병리학적 연구
A Pathologic Study on Granulosa Cell Tumor of the Ovary
- 안선환; 이상국; 이진용; 김승욱; 장윤석
- Issue Date
- 서울대학교 의과대학
- Seoul J Med, Vol.24 No.3, pp. 281-289
- One hundered and ninety-two cases cf ovarian
malignancy were reviewed over a period 0: 22 years
from 1961 to 1982. Of these 13 cases :0.7?"· were
classified as granulosa cell tumor.
All tumors involved unilateral ovaries: right ovary,
6 cases; left, 6 cases; unstated side, 1 case. The
mean age of patients in this series was 3~1. C years;
the tumor was most frequent in the age group of 50
-59 years old. The frequency of nulliparity was 20%.
Sixty percent of the patients were premenopausal
women and 309£ were postmenopausal women.
Clinically the commonest complaint by far was vaginal
bleeding (53.9%). Abdominal mass or distention
(46.2%) and abdominal pain (23.09'0) were also -cornmon symptoms. Physical examination usually
.showed abdominal mass (46.2%) or abdominal distention
(23.1%). The therapeutic regimens most
commonly applied were unilateral salpingo-oophorectomy
(46.296) or total hysterectomy with bilateral
Pathologically the tumor was typically partly or
predominently cystic with yellowish semisolid tumor
tissue. Histopathologically several histologic patterns
were observed in single tumor: the trabecularBllfe ),
microfollicular (60%), and macrofollicular patterns
(5096) were frequent growth patterns. Cystic endometrial
hyperplasia was noted in 2590 of cases and
-endometrial adenocarcinoma in 12.5%.
All five patients on whom follow-up information
is available were alive with no evidence of disease
for 3. G years of average follow-up period. One case
with granulosa cell tumor of diffuse pattern survived
for 10 years.
There were 2 cases of juvenile granulosa cell tumor.
One case was a 1 year and ,) months old child
-who presented vaginal bleeding, breast enlargement,
clitoral enlargement, and pubic hairs. The
·other case was a 12 years old girl who presented
Meigs' syndrome. Both tumors were cystic: one was
partly cystic and partly solid and the other was predominently
cystic. Microscopically classic pattern of
juvenile granulosa cell tumor was noted: macrofollicular
pattern (2 cases), diffuse pattern (I case),
.diffuse luteinization (2 cases), and hyperchromatic
nuclei (2 cases) were apparent. These two patients
were alive without evidence of recurrence.