급성 일산화탄소 중독과 고압 산소요법 간의 경과 시간이 백서의 임신 손모에 미치는 영향

Abstract

Although carbon monoxide (CO) poisoning is the most serious and prevalent noxious gas poisoning in Korea, a few studies have been performed on the effect of hyperbaric oxygenation (HBO) to reduce the pregnancy wastage due to CO exposure during gestational period. Author designed this study to investigate the effect of the time lag on the pregnancy wastage in the management of acute CO poisoning with HBO. Albino rats were exposed to 4,860ppm CO for 20 minutes on the 11th day of gestation, and they were divided into four groups according to the time interval between the cessation of CO exposure and the commencement of HBO(3 ATA, 20 minutes) such as 0 minute-, 30 minutes-, 60 minutes- and no HBO groups. Following findings were observed as the experirnental results, 1. The level of 10% carboxyhemoglobin was used as the criterion of recovery. In the groups of the lag time less than 30 minutes, the elimination time to be recovered was 30~40 minutes. In the groups of lag time more than 60 minutes, that was 70~90 minutes. 2. The pregnancy wastage of the groups whose lag time was more than 60 minutes is higher than that of the groups of lag time less than 30 minutes.