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Clinical efficacy of amniotic membrane transplantation in the treatment of various ocular surface diseases

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Authors
Park, Jung Hyun; Jeoung, Jin Wook; Wee, Won Ryang; Lee, Jin Hak; Kim, Mee Kum; Lee, Jae Lim
Issue Date
2008-02-06
Publisher
Elsevier
Citation
Cont Lens Anterior Eye. 2008;31(2):73-80
Keywords
AdultAgedAmnion/*transplantationCorneal Diseases/*diagnosis/*surgeryFemaleHumansMaleMiddle AgedTreatment Outcome
Abstract
PURPOSE: To investigate the efficacy of permanent amniotic membrane transplantation (AMT) for the treatment of various ocular surface diseases. METHODS: The medical records of 62 eyes from 58 patients who had undergone permanent AMT were reviewed. The amniotic patches were grafted for the treatment of neurotrophic ulcers (n=15), inflammatory corneal ulcers (n=15), scleral ulcers (n=11), painful bullous keratopathy (n=8) and pterygium as an adjuvant to a conjunctival autograft (n=13). Cryo-preserved or freeze-dried amniotic membrane (AM) were used. The overall success rate, the interval to epithelialization, pain-subsiding time, and complications were evaluated. The pain relief and the full epithelialization interval in the bullous keratopathy patients given the cryo-preserved AM were compared with those given the freeze-dried AM. RESULTS: The success rate in the patients with neurotrophic ulcer, inflammatory corneal ulcer, scleral ulcer and bullous keratopathy were 93.3%, 66.7%, 92.9% and 100%, respectively. A conjunctival autograft with AMT showed a 100% success rate without recurrence. The time to re-epithelialization was 24.4+/-24.2, 20.4+/-5.8, and 16.9+/-7.0 days in patients with neurotrophic, inflammatory and scleral ulcers, respectively (p=0.431). The pain relief interval in the cryo-preserved and freeze-dried AM group was 17.7 and 23.3 days, and the re-epithelialization interval was 29 and 22 days, respectively, which was insignificant. CONCLUSIONS: AMT has a high success in the treatment of neurotrophic, scleral ulcer, bullous keratopathy and pterygium with a low rate of complications but presented only partial success in the treatment of inflammatory corneal ulcers. The clinical efficacy of AMT was not related to the methods used to preserve the AM.
ISSN
1367-0484 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18249149

http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6X27-4RPVJ8Y-1-9&_cdi=7263&_user=168665&_orig=search&_coverDate=04%2F30%2F2008&_sk=999689997&view=c&wchp=dGLzVlz-zSkWA&md5=c32cec18218071d3248e2bd1caf6ac4e&ie=/sdarticle.pdf

http://hdl.handle.net/10371/68331
DOI
https://doi.org/10.1016/j.clae.2007.11.004
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College of Medicine/School of Medicine (의과대학/대학원)Ophthalmology (안과학전공)Journal Papers (저널논문_안과학전공)
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