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Diabetes increases large artery diseases, but not small artery diseases in the brain

Cited 18 time in Web of Science Cited 21 time in Scopus
Authors
Kim, Beom Joon; Lee, Seung-Hoon; Kang, Bong Su; Yoon, Byung-Woo; Roh, Jae-Kyu
Issue Date
2008-06-10
Publisher
Springer Verlag
Citation
J Neurol. 255(8):1176-1181
Keywords
AgedCerebral ArterialDiseases/*classification/complications/epidemiology/*etiologyCerebral Arteries/*pathologyDiabetes Mellitus/epidemiology/*physiopathologyFemaleHumansIncidenceInsulin ResistanceMagnetic Resonance Imaging/methodsMaleMiddle AgedProspective StudiesRetrospective StudiesRisk FactorsSex Factors
Abstract
BACKGROUND : It is established that diabetes causes various systemic micro- and macro-vascular complications. Little has been, however, studied on the differential effects of diabetes on the large artery diseases (LAD) or small artery disease (SAD) in the brain. The purpose of this study was to examine an association of diabetes on the incidence of underlying LAD versus SAD in ischemic stroke patients. METHODS : We prospectively collected 523 acute ischemic stroke patients without cardioembolic causes or other determined causes of stroke. Using brain MRI, the cerebral LAD (extracranial and intracranial arterial stenosis of 50 % or more) and the cerebral SAD (old lacunar infarction, microbleeds and leukoaraiosis) findings were assessed. Information regarding vascular risk factor was also collected. RESULTS : Among the patients (male, n = 342; diabetes, n = 200), diabetes was not associated with the presence of LADs or SADs in female subjects, but strongly with the presence of intracranial LAD in male subjects (p < 0.01). The association remained significant (OR 2.09, 95 %CI 1.25-3.51) after adjusting for major confounders. A similar association was also found in intracranial LAD and insulin resistance. There was, however, no significant association of diabetes with SAD in male nor in female patients. CONCLUSIONS : Our results showed that diabetes is associated with the frequency of intracranial LAD, especially in males. Out study may be regarded as evidence of differential biological effects of diabetes on cerebral vasculature.
ISSN
0340-5354 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18537055

http://www.springerlink.com/content/t16370210825r517/fulltext.pdf

http://hdl.handle.net/10371/68395
DOI
https://doi.org/10.1007/s00415-008-0864-0
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Neurology (신경과학교실)Journal Papers (저널논문_신경과학교실)
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