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Glial expression of interleukin-18 and its receptor after excitotoxic damage in the mouse hippocampus

Cited 25 time in Web of Science Cited 26 time in Scopus
Authors
Jeon, Gye Sun; Park, Sung Kyung; Park, Sang Wook; Kim, Dong Woon; Chung, Chun Kee; Cho, Sa Sun
Issue Date
2007-08-22
Publisher
Springer Verlag
Citation
Neurochem Res. 33(1):179-184
Keywords
AnimalsBlotting, WesternHippocampus/*drug effects/metabolismImmunohistochemistryInterleukin-18/*metabolismKainic Acid/*toxicityMaleMiceMice, Inbred ICRNeuroglia/*metabolismReceptors, Interleukin-18/*metabolism
Abstract
Interleukin (IL)-18, a member of the IL-1 cytokine family, is an important mediator of peripheral inflammation and host defence responses. However, although IL-1 is a key proinflammatory cytokine in the brain, little is known about IL-18 changes in glial cells under excitotoxic neurodegeneration. In this study, we characterized the expressions of IL-18 and IL-18 receptor (IL-18R) in kainic acid (KA)-induced excitotoxicity in mouse hippocampus by immunohistochemistry and Western blotting. IL-18 immunoreactivity was found in microglia whereas IL-18R immunoreactivity was observed in astrocytes. Levels of IL-18 and IL-18R in hippocampus homogenates increased progressively from day 1 post-KA and peaked at 3 days. This study demonstrates the cellular sources of IL-18 and IL-18R, and their temporal correlations after KA-insult, and suggests roles for IL-18 and IL-18R in glial cells in response to excitotoxic damage in the hippocampus.
ISSN
0364-3190 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17710540

http://www.springerlink.com/content/l440771644462741/fulltext.pdf

http://hdl.handle.net/10371/68408
DOI
https://doi.org/10.1007/s11064-007-9434-6
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College of Medicine/School of Medicine (의과대학/대학원)Neurosurgery (신경외과학전공)Journal Papers (저널논문_신경외과학전공)
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