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Glial expression of interleukin-18 and its receptor after excitotoxic damage in the mouse hippocampus

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dc.contributor.authorJeon, Gye Sun-
dc.contributor.authorPark, Sung Kyung-
dc.contributor.authorPark, Sang Wook-
dc.contributor.authorKim, Dong Woon-
dc.contributor.authorChung, Chun Kee-
dc.contributor.authorCho, Sa Sun-
dc.date.accessioned2010-07-07T03:12:12Z-
dc.date.available2010-07-07T03:12:12Z-
dc.date.issued2007-08-22-
dc.identifier.citationNeurochem Res. 33(1):179-184en
dc.identifier.issn0364-3190 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17710540-
dc.identifier.urihttp://www.springerlink.com/content/l440771644462741/fulltext.pdf-
dc.identifier.urihttps://hdl.handle.net/10371/68408-
dc.description.abstractInterleukin (IL)-18, a member of the IL-1 cytokine family, is an important mediator of peripheral inflammation and host defence responses. However, although IL-1 is a key proinflammatory cytokine in the brain, little is known about IL-18 changes in glial cells under excitotoxic neurodegeneration. In this study, we characterized the expressions of IL-18 and IL-18 receptor (IL-18R) in kainic acid (KA)-induced excitotoxicity in mouse hippocampus by immunohistochemistry and Western blotting. IL-18 immunoreactivity was found in microglia whereas IL-18R immunoreactivity was observed in astrocytes. Levels of IL-18 and IL-18R in hippocampus homogenates increased progressively from day 1 post-KA and peaked at 3 days. This study demonstrates the cellular sources of IL-18 and IL-18R, and their temporal correlations after KA-insult, and suggests roles for IL-18 and IL-18R in glial cells in response to excitotoxic damage in the hippocampus.en
dc.description.sponsorshipThis study was supported by the second stage
Brain Korea 21 Project in 2007 and a grant (M103KV010018
04K2201 01850) from Brain Research Center of the 21st Century
Frontier Research Program funded by the Ministry of Science and
Technology, the Republic of Korea.
en
dc.language.isoenen
dc.publisherSpringer Verlagen
dc.subjectAnimalsen
dc.subjectBlotting, Westernen
dc.subjectHippocampus/*drug effects/metabolismen
dc.subjectImmunohistochemistryen
dc.subjectInterleukin-18/*metabolismen
dc.subjectKainic Acid/*toxicityen
dc.subjectMaleen
dc.subjectMiceen
dc.subjectMice, Inbred ICRen
dc.subjectNeuroglia/*metabolismen
dc.subjectReceptors, Interleukin-18/*metabolismen
dc.titleGlial expression of interleukin-18 and its receptor after excitotoxic damage in the mouse hippocampusen
dc.typeArticleen
dc.contributor.AlternativeAuthor전계선-
dc.contributor.AlternativeAuthor박성경-
dc.contributor.AlternativeAuthor박상욱-
dc.contributor.AlternativeAuthor김동운-
dc.contributor.AlternativeAuthor정천기-
dc.contributor.AlternativeAuthor조사선-
dc.identifier.doi10.1007/s11064-007-9434-6-
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