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Increace in Intracellular Calcium is Necessary for RANKL Induction by High Extrecellular Calcium
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Gwan-Shik | - |
dc.contributor.author | Jun, Ji-Hae | - |
dc.contributor.author | Kim, Hyung-Keun | - |
dc.contributor.author | Woo, Kyung-Mi | - |
dc.contributor.author | Baek, Jeong-Hwa | - |
dc.date.accessioned | 2010-07-12T05:46:33Z | - |
dc.date.available | 2010-07-12T05:46:33Z | - |
dc.date.issued | 2005-03 | - |
dc.identifier.citation | International Journal of Oral Biology 30:9-15 | en |
dc.identifier.issn | 1226-7155 | - |
dc.identifier.uri | https://hdl.handle.net/10371/68595 | - |
dc.description.abstract | Recently, we reported that high extracellular calcium increased receptor activator of nuclear factor-kB ligand(RANKL) expression via p44/42 mitogen-activated protein kinase (p44/42 MAPK) activation in mouse osteoblasts. However, the mechanism for p44/42 MAPK activation by high extracellular calcium is unclear. In this study, we examined the role of intracellular calcium increase in high extracellular calcium-induced RANKL induction and p44/42 MAPK activation. Primary cultured mouse calvarial osteoblasts were used. RANKL expression was highly induced by 10 mM calcium treatment. Ionomycin, a calcium ionophore, also increased RANKL expression and activated p44/42 MAPK. U0126, an inhibitor of MEK1/2, an upstream activator of p44/42 MAPK, blocked the RANKL induction by both high extracellular calcium and ionomycin. High extracellular calcium increased the phosphorylation of proline-rich tyrosine kinase 2 (Pyk2), one of the known upstream regulators of p44/42 MAPK activation.... | en |
dc.language.iso | en | en |
dc.publisher | Korean Acadamy of Oral Biology | en |
dc.subject | high extracellular calcium | en |
dc.subject | RANKL | en |
dc.subject | p44/42 MAPK | en |
dc.subject | intracellular calcium | en |
dc.subject | Pyk2 | en |
dc.subject | Calcineurin | en |
dc.title | Increace in Intracellular Calcium is Necessary for RANKL Induction by High Extrecellular Calcium | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김관식 | - |
dc.contributor.AlternativeAuthor | 전지혜 | - |
dc.contributor.AlternativeAuthor | 김형근 | - |
dc.contributor.AlternativeAuthor | 우경미 | - |
dc.contributor.AlternativeAuthor | 백정화 | - |
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