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Recovery of stem cells from cryopreserved periodontal ligament
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Seo, B-M | - |
dc.contributor.author | Miura, M | - |
dc.contributor.author | Sonoyama, W | - |
dc.contributor.author | Coppe, C | - |
dc.date.accessioned | 2010-07-23T03:18:22Z | - |
dc.date.available | 2010-07-23T03:18:22Z | - |
dc.date.issued | 2005-10 | - |
dc.identifier.citation | Journal of Dental Research 84:907-912 | en |
dc.identifier.issn | 0022-0345 | - |
dc.identifier.uri | https://hdl.handle.net/10371/68674 | - |
dc.description.abstract | Human post-natal stem cells possess a great potential to be utilized in stem-cell-mediated clinical therapies and tissue engineering. It is not known whether cryopreserved human tissues contain functional post-natal stem cells. In this study, we utilized human periodontal ligament to test the hypothesis that cryopreserved human periodontal ligament contains retrievable post-natal stem cells. These cryopreserved periodontal ligament stem cells maintained normal periodontal ligament stem cell characteristics, including expression of the mesenchymal stem cell surface molecule STRO-1, single-colony-strain generation, multipotential differentiation, cementum/periodontal-ligament-like tissue regeneration, and a normal diploid karyotype. Collectively, this study provides valuable evidence demonstrating a practical approach to the preservation of solid-frozen human tissues for subsequent post-natal stem cell isolation and tissue regeneration. The present study demonstrates that human post-natal stem cells can be recovered from cryopreserved human periodontal ligament, thereby providing a practical clinical approach for the utilization of frozen tissues for stem cell isolation. | en |
dc.language.iso | en | en |
dc.publisher | American and International Associations for Dental | en |
dc.subject | periodontal ligament stem cells(PDLSCs) | en |
dc.subject | osteoblast | en |
dc.subject | cementum | en |
dc.subject | cryopreservation | en |
dc.title | Recovery of stem cells from cryopreserved periodontal ligament | en |
dc.type | Article | en |
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