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Identification of tendon stemprogenitor cells and the role of the extracellular matrix in their niche

Cited 724 time in Web of Science Cited 776 time in Scopus
Authors
Seo, Byoung-Moo; Bi, Yanming; Ehirchiou, Driss; Kilts, Tina M; Inkson, Colette A; Embree, Mildred C; Sonoyama, Wataru; Li, Li; Leet, Arabella I; Zhang, Li; Shi, Songtao; Young, Marian F
Issue Date
2007-09
Publisher
Nature Publishing Group
Citation
Nature Medicine 13, 1219-1227
Abstract
The repair of injured tendons remains a great challenge, largely owing to a lack of in-depth characterization of tendon cells and their precursors. We show that human and mouse tendons harbor a unique cell population, termed tendon stem/progenitor cells (TSPCs), that has universal stem cell characteristics such as clonogenicity, multipotency and self-renewal capacity. The isolated TSPCs could regenerate tendon-like tissues after extended expansion in vitro and transplantation in vivo. Moreover, we show that TSPCs reside within a unique niche predominantly comprised of an extracellular matrix, and we identify biglycan (Bgn) and fibromodulin (Fmod) as two critical components that organize this niche. Depletion of Bgn and Fmod affects the differentiation of TSPCs by modulating bone morphogenetic protein signaling and impairs tendon formation in vivo. Our results, while offering new insights into the biology of tendon cells, may assist in future strategies to treat tendon diseases.
ISSN
1078-8956
Language
English
URI
http://hdl.handle.net/10371/68680
DOI
https://doi.org/10.1038/nm1630
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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