Browse

Absence of long-term depression in the visual cortex of glutamic Acid decarboxylase-65 knock-out mice.

DC Field Value Language
dc.contributor.authorChoi, Se-Young-
dc.contributor.authorMorales, Bernardo-
dc.contributor.authorLee, Hey-Kyoung-
dc.contributor.authorKirkwood, Alfredo-
dc.date.accessioned2010-07-23T04:29:26Z-
dc.date.available2010-07-23T04:29:26Z-
dc.date.issued2002-07-
dc.identifier.citationJournal of Neuroscience, 22(13):5271–5276en
dc.identifier.issn0270-6474-
dc.identifier.urihttp://hdl.handle.net/10371/68687-
dc.description.abstractLong-term depression (LTD) is widely considered a mechanism for experience-induced synaptic weakening in the brain. Recent in vivo studies on glutamic acid decarboxylase [GAD 65 (/)] knock-out mice indicates that GABAergic synaptic inhibition is also required for the normal weakening of deprived inputs in the visual cortex. To better understand how GABAergic inhibition might control plasticity, we assessed the status of synaptic inhibition and LTD in visual cortical slices of GAD 65 knock-out mice. We found the following: (1) the efficacy of GABAergic synapses during repetitive activation is reduced in GAD 65 (/) mice; (2) the induction of LTD is impaired in the visual cortex of GAD 65 (/) mice; and (3) chronic, but not acute, treatment with the benzodiazepine agonist diazepam restores LTD in GAD 65 (/) mice. These results suggest that a certain inhibitory tone is required for the induction of LTD in visual cortex. We propose that the lack of visual cortical LTD in GAD 65 (/) may account for the lack of experience-dependent plasticity in these mice.en
dc.language.isoenen
dc.publisherSociety for Neuroscienceen
dc.subjectcritical perioden
dc.subjectsynaptic plasticityen
dc.subjectGABAen
dc.subjectneocortexen
dc.subjectIPSCen
dc.subjectsynaptic inhibitionen
dc.titleAbsence of long-term depression in the visual cortex of glutamic Acid decarboxylase-65 knock-out mice.en
dc.typeArticleen
dc.contributor.AlternativeAuthor최세영-
dc.contributor.AlternativeAuthor이혜경-
Appears in Collections:
College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
Files in This Item:
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse