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In vitro degradation behaviour of non-porous ultra-finepoly(glycolic acid)/poly(L-lactic acid) fibres and porousultra-fine poly(glycolic acid) fibres
Cited 71 time in
Web of Science
Cited 82 time in Scopus
- Authors
- Issue Date
- 2005-12
- Publisher
- Elsevier
- Citation
- Polymer Degradation and Stability 2005;90:441-448
- Keywords
- poly(glycolic acid) ; poly(ㄴ-lactic acid) ; electrospinning ; porous ultra fine fibre ; biodegradability
- Abstract
- The in vitro degradation behaviour of non-porous ultra-fine poly(glycolic acid)/poly(l-lactic acid) (PGA/PLA) fibres and porous ultra-fine PGA fibres was investigated. The non-porous ultra-fine PGA/PLA fibres were prepared by electrospinning of a PGA/PLA solution in 1,1,1,3,3,3-hexafluoro-2-propanol and the porous ultra-fine PGA fibres were obtained from them via selective removal of PLA with chloroform. Since PLA has a lower degradation rate than PGA, the degradation rates of the ultra-fine PGA/PLA fibres decreased with increasing content of PLA. The porous ultra-fine PGA fibres were degraded in vitro in the order of non-porous PGA > P-PGA/PLA(90/10) > P-PGA/PLA(70/30) > P-PGA/PLA(50/50) > P-PGA/PLA(30/70) due to autocatalytic hydrolysis.
- ISSN
- 0141-3910
- Language
- English
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