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Investigation of the beta-catenin gene in a case of dentinogenicghost cell tumor

Cited 17 time in Web of Science Cited 19 time in Scopus
Authors
Park, Joo-Cheol; Kim, Soo-A; Ahn, Sang-Gun; Kim, Su-Gwan; Lee, Sang-Ho; Kim, Jin; Yoon, Jung-Hoon
Issue Date
2007-01
Publisher
Elsevier
Citation
Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontics 2007;103:97-101
Abstract
Dentinogenic ghost cell tumor (DGCT) is considered as a neoplastic counterpart of the calcifying odontogenic cyst (COC). β-catenin mutations have been described in COC suggesting a critical role in its histogenesis. In this study, we report a patient with DGCT contains a missense mutation on codon 3 (ACT → TCT) of β-catenin gene. Immunohistochemistry showed nuclear, cytoplasmic, and membranous accumulation of β-catenin in the tumor cells. TUNEL assay showed positive signals in nucleated cells adjacent to the ghost cells. Our data suggest that β-catenin plays an important role in the tumorigenesis of DGCT. DGCT may develop by an improper differentiation process coordinated by Wnt signaling pathway. Further studies are needed to determine the genotypic/phenotypic characteristics of ghost cell–containing odontogenic lesions.
ISSN
1079-2104
Language
English
URI
http://hdl.handle.net/10371/68699
DOI
https://doi.org/10.1016/j.tripleo.2005.10.037
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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