Publications
Detailed Information
Investigation of the beta-catenin gene in a case of dentinogenicghost cell tumor
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Joo-Cheol | - |
dc.contributor.author | Kim, Soo-A | - |
dc.contributor.author | Ahn, Sang-Gun | - |
dc.contributor.author | Kim, Su-Gwan | - |
dc.contributor.author | Lee, Sang-Ho | - |
dc.contributor.author | Kim, Jin | - |
dc.contributor.author | Yoon, Jung-Hoon | - |
dc.date.accessioned | 2010-07-23T05:49:37Z | - |
dc.date.available | 2010-07-23T05:49:37Z | - |
dc.date.issued | 2007-01 | - |
dc.identifier.citation | Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontics 2007;103:97-101 | en |
dc.identifier.issn | 1079-2104 | - |
dc.identifier.uri | https://hdl.handle.net/10371/68699 | - |
dc.description.abstract | Dentinogenic ghost cell tumor (DGCT) is considered as a neoplastic counterpart of the calcifying odontogenic cyst (COC). β-catenin mutations have been described in COC suggesting a critical role in its histogenesis. In this study, we report a patient with DGCT contains a missense mutation on codon 3 (ACT → TCT) of β-catenin gene. Immunohistochemistry showed nuclear, cytoplasmic, and membranous accumulation of β-catenin in the tumor cells. TUNEL assay showed positive signals in nucleated cells adjacent to the ghost cells. Our data suggest that β-catenin plays an important role in the tumorigenesis of DGCT. DGCT may develop by an improper differentiation process coordinated by Wnt signaling pathway. Further studies are needed to determine the genotypic/phenotypic characteristics of ghost cell–containing odontogenic lesions. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.title | Investigation of the beta-catenin gene in a case of dentinogenicghost cell tumor | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 박주철 | - |
dc.contributor.AlternativeAuthor | 김수아 | - |
dc.contributor.AlternativeAuthor | 안상건 | - |
dc.contributor.AlternativeAuthor | 김수관 | - |
dc.contributor.AlternativeAuthor | 이상호 | - |
dc.contributor.AlternativeAuthor | 김진 | - |
dc.contributor.AlternativeAuthor | 연정훈 | - |
dc.identifier.doi | 10.1016/j.tripleo.2005.10.037 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.