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An in Vitro and in Vivo Investigation of the Anti-caries Activity of Medium-chain Fatty Acids

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Authors
Min, Byung Mu; Lee, Gene; Kim, Kang-ju; Ku, Young; Woo, Kyung Mi; Kim, Myong Soo; Chung, Chong-pyoung
Issue Date
2004-03
Publisher
Korean Academy of Oral Biology
Citation
International journal of oral biology 29(1):13-20
Keywords
medium-chain fatty acidsacidogenic plaque bacteriaacid productionpolysaccharide synthesisrat caries
Abstract
Fatty acids (FA)have been known to have a caries-protective effect for many years and show bactericidal and surface-active properties. This work was undertaken to compare the degree of caries protection offered by medium-chain FA with chain lengths of 9-12 carbons and to assess the anti-caries potential of sodium laurate, which showed the greatest anti-caries effect among the FA tested. The sodium salts of FA significantly reduced plaque bacterial metabolism by 7 standard strains of acidogenic bacteria in a dose-dependent manner and the order of bacterial metabolism reduction was from sodium laurate to decanoate to nonanoate. Because sodium laurate showed maximum anti-caries potential in vitro, we further examined directly its anti-caries effect using an in vivo rat model. Sodium laurate also produced a highly significant reduction in caries occurrence compared to that of control and gave a greater degree of caries prevention than fluoride in vivo. Our results indicate that the salt form of laurate has a very strong anti-caries effect in vitro and in vivo.
ISSN
1226-7155
Language
English
URI
http://hdl.handle.net/10371/68729
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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