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Induction method of tyrosine kinase A-medicated cell death in rat pheochromocytoma

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Authors
Kim, Hyun-Jeong; Ahn, Jin-Young; Kang, Lami; Kang, Hyejin; Kim, Sung-Hoon; Kim, Je-Yong; Kim, Seung Ki; Wang, Kyu-Chang; Cho, Byung Kyu; Lee, Kwang-Woo; Roh, Jae-Kyu; Kim, Manho
Issue Date
2005-04
Publisher
Springer Verlag
Citation
Biotechnology Letters 27: 583-587
Keywords
apoptosisnerve growth factorrat pheochromocytoma PC12 celltyrosine kinase A
Abstract
Nerve Growth Factor (NGF) is a neurotrophic factor that prevents apoptosis in neuronal progenitor cells. In rat pheochromocytoma (PC12) cells, tyrosine kinase A receptor (TrkA) mediates neurotrophic or protective effects, while p75 neurotrophin receptor (p75NTR) functions as a death receptor. We have determined whether TrkA mediates any cytotoxic effect. Following serum deprivation, TrkA expression increased 2.2-fold and apoptosis began with expression of Bax proapoptotic protein. Application of NGF halved cell viability but this was reversed by K252a, the TrkA inhibitor. These results confirmed the paradoxical cytotoxic effect of neurotrophic NGF via TrkA in PC12 cells following serum deprivation.
ISSN
0141-5492
Language
English
URI
http://hdl.handle.net/10371/68834
DOI
https://doi.org/10.1007/S10529-005-2884-5
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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