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Induction method of tyrosine kinase A-medicated cell death in rat pheochromocytoma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Hyun-Jeong | - |
dc.contributor.author | Ahn, Jin-Young | - |
dc.contributor.author | Kang, Lami | - |
dc.contributor.author | Kang, Hyejin | - |
dc.contributor.author | Kim, Sung-Hoon | - |
dc.contributor.author | Kim, Je-Yong | - |
dc.contributor.author | Kim, Seung Ki | - |
dc.contributor.author | Wang, Kyu-Chang | - |
dc.contributor.author | Cho, Byung Kyu | - |
dc.contributor.author | Lee, Kwang-Woo | - |
dc.contributor.author | Roh, Jae-Kyu | - |
dc.contributor.author | Kim, Manho | - |
dc.date.accessioned | 2010-08-02T01:13:08Z | - |
dc.date.available | 2010-08-02T01:13:08Z | - |
dc.date.issued | 2005-04 | - |
dc.identifier.citation | Biotechnology Letters 27: 583-587 | en |
dc.identifier.issn | 0141-5492 | - |
dc.identifier.uri | https://hdl.handle.net/10371/68834 | - |
dc.description.abstract | Nerve Growth Factor (NGF) is a neurotrophic factor that prevents apoptosis in neuronal progenitor cells. In rat pheochromocytoma (PC12) cells, tyrosine kinase A receptor (TrkA) mediates neurotrophic or protective effects, while p75 neurotrophin receptor (p75NTR) functions as a death receptor. We have determined whether TrkA mediates any cytotoxic effect. Following serum deprivation, TrkA expression increased 2.2-fold and apoptosis began with expression of Bax proapoptotic protein. Application of NGF halved cell viability but this was reversed by K252a, the TrkA inhibitor. These results confirmed the paradoxical cytotoxic effect of neurotrophic NGF via TrkA in PC12 cells following serum deprivation. | en |
dc.description.sponsorship | This work was supported by S.N.U foundation &
Overhead Research Fund (Grant No; 00-3-3-37) and by grant no. 03-2002-092 from the SNUH Research Fund. | en |
dc.language.iso | en | en |
dc.publisher | Springer Verlag | en |
dc.subject | apoptosis | en |
dc.subject | nerve growth factor | en |
dc.subject | rat pheochromocytoma PC12 cell | en |
dc.subject | tyrosine kinase A | en |
dc.title | Induction method of tyrosine kinase A-medicated cell death in rat pheochromocytoma | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김현정 | - |
dc.contributor.AlternativeAuthor | 안진영 | - |
dc.contributor.AlternativeAuthor | 강라미 | - |
dc.contributor.AlternativeAuthor | 강혜진 | - |
dc.contributor.AlternativeAuthor | 김성훈 | - |
dc.contributor.AlternativeAuthor | 김재영 | - |
dc.contributor.AlternativeAuthor | 김승기 | - |
dc.contributor.AlternativeAuthor | 양규창 | - |
dc.contributor.AlternativeAuthor | 조병규 | - |
dc.contributor.AlternativeAuthor | 노재규 | - |
dc.contributor.AlternativeAuthor | 김만호 | - |
dc.identifier.doi | 10.1007/S10529-005-2884-5 | - |
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