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Design and biological activity of synthetic oligopeptides with Pro-His-Ser-Arg-Asn (PHSRN) and Arg-Gly-Asp (RGD) motifs for human osteoblast-like cell (MG-63) adhesion
Cited 17 time in
Web of Science
Cited 18 time in Scopus
- Authors
- Issue Date
- 2002
- Publisher
- Springer Verlag
- Citation
- Biotechnology Letters 24: 2029–2033
- Abstract
- A synthetic oligopeptide, composed of Arg-Gly-Asp (RGD) and its synergistic Pro-His-Ser-Arg-Asn (PHSRN)
motifs and a six glycines (G6) linker, promoted human osteoblast-like cell (MG-63) adhesion, spreading and
mitogen-activated protein kinase (MAPK) activity in a similar manner to a positive fibronectin control. This
synthetic oligopeptide may therefore be a useful osteo-inductive material.
- ISSN
- 0141-5492
- Language
- English
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