S-Space College of Dentistry/School of Dentistry (치과대학/치의학대학원) Dept. of Dentistry (치의학과) Journal Papers (저널논문_치의학과)
Design and biological activity of synthetic oligopeptides with Pro-His-Ser-Arg-Asn (PHSRN) and Arg-Gly-Asp (RGD) motifs for human osteoblast-like cell (MG-63) adhesion
- Kim, Tae-Il; Jang, Jun-Hyeog; Lee, Yong-Moo; Ryu, In-Cheol; Chung, Chong-Pyoung; Han, Soo-Boo; Choi, Sang-Mook; Ku, Young
- Issue Date
- Springer Verlag
- Biotechnology Letters 24: 2029–2033
- A synthetic oligopeptide, composed of Arg-Gly-Asp (RGD) and its synergistic Pro-His-Ser-Arg-Asn (PHSRN)
motifs and a six glycines (G6) linker, promoted human osteoblast-like cell (MG-63) adhesion, spreading and
mitogen-activated protein kinase (MAPK) activity in a similar manner to a positive fibronectin control. This
synthetic oligopeptide may therefore be a useful osteo-inductive material.
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