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Design and biological activity of synthetic oligopeptides with Pro-His-Ser-Arg-Asn (PHSRN) and Arg-Gly-Asp (RGD) motifs for human osteoblast-like cell (MG-63) adhesion

Cited 15 time in Web of Science Cited 16 time in Scopus
Authors
Kim, Tae-Il; Jang, Jun-Hyeog; Lee, Yong-Moo; Ryu, In-Cheol; Chung, Chong-Pyoung; Han, Soo-Boo; Choi, Sang-Mook; Ku, Young
Issue Date
2002
Publisher
Springer Verlag
Citation
Biotechnology Letters 24: 2029–2033
Keywords
fibronectinmitogen-activated protein kinaseoligopeptidesosteoblast-like cell
Abstract
A synthetic oligopeptide, composed of Arg-Gly-Asp (RGD) and its synergistic Pro-His-Ser-Arg-Asn (PHSRN)
motifs and a six glycines (G6) linker, promoted human osteoblast-like cell (MG-63) adhesion, spreading and
mitogen-activated protein kinase (MAPK) activity in a similar manner to a positive fibronectin control. This
synthetic oligopeptide may therefore be a useful osteo-inductive material.
ISSN
0141-5492
Language
English
URI
http://hdl.handle.net/10371/68835
DOI
https://doi.org/10.1023/A:1021368519336
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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