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Bioactivity, Pre-Osteoblastic Cell Responses, and Osteoconductivity Evaluations of the Electrospun Non-Woven SiO2-CaO Gel Fabrics

Cited 17 time in Web of Science Cited 19 time in Scopus
Authors
Seol, Yang-Jo; Kim, Kyoung-Hwa; Kang, Young Mi; Kim, In Ae; Rhee, Sang-Hoon
Issue Date
2009
Publisher
Wiley-Blackwell
Citation
Journal of Biomedical Materials Research Part B 90B: 679–687
Keywords
SiO2–CaO gelelectrospinningbioactivitypre-osteoblastic cell responseosteoconductivity
Abstract
The evaluations of the fibers characteristics, bioactivity, pre-osteoblastic cell
responses, and osteoconductivity of the non-woven SiO2–CaO gel fabric made by electrospinning
method was carried out. Silica gels with four different calcium contents were prepared by
condensation following hydrolysis of tetraethyl orthosilicate under acidic conditions. The
molar ratios of Ca to Si prepared ranged from 0 to 0.15. SiO2–CaO gel fabrics were heattreated
at 3008C for 3 h after spinning under an electric field of 2 kV/cm. As the Ca to Si ratio
increased, the diameter of electrospun SiO2–CaO gel fibers increased because the viscosity of
the SiO2–CaO gel solution increased. The apatite-forming ability of heat-treated, non-woven
SiO2–CaO gel fabric was evaluated in simulated body fluid and tended to increase with an
increasing Ca to Si molar ratio. However, proliferation and differentiation tended to decrease
with an increasing Ca to Si molar ratio. The sample which had the Ca to Si ratio as 0.10
showed good osteoconductivity in vivo in the calvarial defect New Zealand white rabbit model
compared to that had the Ca to Si ratio as 0 and empty defect. These results strongly suggest
that non-woven SiO2–CaO gel fabric made by the electrospinning method has potential for
application as a bone grafting material.
ISSN
1552-4973
Language
English
URI
http://hdl.handle.net/10371/68841
DOI
https://doi.org/10.1002/jbm.b.31334
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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