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Biological efficacy of silk fibroin nanofiber membranes for guided bone regeneration

Cited 226 time in Web of Science Cited 250 time in Scopus
Authors
Kim, Kyoung-Hwa; Jeong, Lim; Park, Ho-Nam; Shin, Seung-Yun; Park, Won-Ho; Lee, Sang-Chul; Kim, Tae-Il; Park, Yoon-Jeong; Seol, Yang-Jo; Lee, Yong-Moo; Ku, Young; Rhyu, In-Chul; Han, Soo-Boo; Chung, Chong-Pyoung
Issue Date
2005
Publisher
Elsevier
Citation
Journal of Biotechnology 120, 327–339
Keywords
Silk fibroinNanofiberMembraneGuided bone regeneration
Abstract
The favorable biological properties of silk fibroin (SF) nanofiber membrane make it a good candidate for clinical applications
as a device in bone and periodontal regenerative therapy. The purpose of this study is to evaluate the biocompatibility of the SF
nanofiber membrane, and to examine its effect on bone regeneration in a rabbit calvarial model.
To examine the biocompatibility of the electrospun SF membrane, we investigated cell proliferation, morphology, and differentiation.
The bone regenerative efficacy of the membrane was evaluated in the calvarial defect of rabbits.
The cell numbers and osteocalcin production labels were significantly increased in accordance with culture period. Cells had
a stellate shape and broad cytoplasmic extensions on the membrane. The cells showed activity of ALPase that was comparable
to culture dishes, and were calcified similarly to culture dishes. In in vivo tests, a complete bony union across the defects was
observed after 8 weeks. At 12 weeks, the defect had completely healed with new bone.
In conclusion, the SF nanofiber membrane was shown to possess good biocompatibility with enhanced bone regeneration and
no evidence of any inflammatory reaction. These results strongly suggest that the SF membrane should be useful as a tool for
guided bone regeneration.
ISSN
0168-1656
Language
English
URI
http://hdl.handle.net/10371/68910
DOI
https://doi.org/10.1016/j.jbiotec.2005.06.033
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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