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Effects of a bisphosphonate on the expression of bone specific genes after autogenous free bone grafting in rats.

Cited 17 time in Web of Science Cited 20 time in Scopus
Authors
Myoung, Hoon; Park, Ju-Yong; Choung, Pill-Hoon
Issue Date
2001-08
Publisher
Wiley-Blackwell
Citation
J Periodontal Res. 2001;36(4):244-251
Keywords
bisphosphonatesbone specific genesautogenous bone graft
Abstract
The purpose of this study was to evaluate the clinical availability of a bisphosphonate in autogenous free bone grafts. Bisphosphonate (0.01 mg/kg/day) was administered daily after an autogenous free bone graft on a rat calvarium. The effects of a bisphosphonate on the resorption of grafted bone and mRNA expression in bone specific genes, i.e. bone morphogenetic protein 2, bone morphogenetic protein 4, alkaline phosphatase, osteocalcin, osteoclast inhibitory factor and calcitonin receptor, were studied via a reverse transcription‐polymerase chain reaction (RT‐PCR), real time RT‐PCR and tartrate‐resistant alkaline phosphatase (TRAP) staining. In a clinical and histomorphological review, bone resorption decreased in the experimental group in contrast to the control group where active bone resorption was observed. Bisphosphonate altered not only the mRNA expression of the bone resorption associated genes but also the bone formation associated genes. The expression of the calcitonin receptor (CTR) mRNA was not detected and the osteoclast inhibitory factor (OCIF) was significantly up‐regulated in the experimental group as opposed to the control group. The expressions of osteocalcin and alkaline phosphatase mRNAs were also higher in the experimental group. However, there was no significant difference in the mRNA expression of bone morphogenetic proteins between the two groups. The data suggest the possibility of a clinical application of bisphosphonates for decreasing resorption of grafted bone
ISSN
0022-3484
Language
English
URI
http://hdl.handle.net/10371/68914
DOI
https://doi.org/10.1034/j.1600-0765.2001.036004244.x
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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