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"The extracellular loop 2 of TM4SF5 inhibits integrin a2 on hepatocytes under collagen

Cited 22 time in Web of Science Cited 22 time in Scopus
Authors
Kim, Hyun Jeong; Lee, Sin-Ae; Kim, Young Mee; Kwak, Tae Kyoung; Kim, Semi; Ko, Wonil; Kim, Sung-Hoon; Park, Ki Hun; Cho, Moonjae; Lee, Jung Weon
Issue Date
2009-09
Publisher
Oxford University Press
Citation
Carcinogenesis 30, 1872-1879
Abstract
Four-transmembrane L6 family member 5 (TM4SF5) and its homolog L6, a tumor antigen, form a four-transmembrane L6 family. TM4SF5 expression causes uncontrolled cell proliferation and angiogenesis. Although other genuine transmembrane 4 superfamily (TM4SF) members co-operate with integrins for cell migration, roles of TM4SF5 in the cellular spreading and migration are unknown. Using hepatocarcinoma cell clones that ectopically express TM4SF5, we found that cross talks via an extracellular interaction between TM4SF5 and integrin 2 in collagen type I environment inhibited integrin 2 functions such as spreading on and migration toward collagen I, which were recovered by suppression of TM4SF5 or structural disturbance of its second extracellular loop using a peptide or mutagenesis. Altogether, the observations suggest that TM4SF5 in hepatocytes negatively regulates integrin 2 function via an interaction between the extracellular loop 2 of TM4SF5 and integrin 2 during cell spreading on and migration through collagen I environment.
ISSN
0143-3334
Language
English
URI
http://hdl.handle.net/10371/68966
DOI
https://doi.org/10.1093/carcin/bgp234
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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