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Prognostic value of activated Akt expression in oral squamous cell carcinoma.
DC Field | Value | Language |
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dc.contributor.author | Hong, S-P | - |
dc.contributor.author | Lim, J | - |
dc.contributor.author | Kim, J-H | - |
dc.contributor.author | Paeng, J-Y | - |
dc.contributor.author | Kim, M-J | - |
dc.contributor.author | Hong, S-D | - |
dc.contributor.author | Lee, J-I | - |
dc.date.accessioned | 2010-08-05T05:44:40Z | - |
dc.date.available | 2010-08-05T05:44:40Z | - |
dc.date.issued | 2005-03 | - |
dc.identifier.citation | Journal of Clinical Pathology 2005;58:1199-1205 | en |
dc.identifier.issn | 0021-9746 | - |
dc.identifier.uri | https://hdl.handle.net/10371/68985 | - |
dc.description.abstract | Background: Akt is a serine/threonine kinase that plays an important role in tumorigenesis and influences prognosis in several cancers. However, its importance in oral squamous cell carcinomas (OSCC) has not been elucidated.
Aim: To investigate the association between the expression of activated Akt, clinicopathological factors, and E-cadherin, PCNA (proliferating cell nuclear antigen), and VEGF (vascular endothelial growth factor) expression to verify the validity of Akt as a prognostic factor in OSCC. Methods: Phosphorylated Akt (p-Akt), E-cadherin, PCNA, and VEGF expression were assessed immunohistochemically in 84 OSCCs. The results were analysed in relation to clinicopathological factors. Results: p-Akt was expressed in 29 cases. It was significantly correlated with lymph node metastasis, TNM stage, and E-cadherin expression. Univariate analysis showed that p-Akt expression, E-cadherin expression, PCNA expression, differentiation, tumour size, lymph node metastasis, TNM stage, and recurrence correlated with prognosis. Multivariate analysis showed that p-Akt expression is an independent prognostic factor in patients with OSCC. Conclusions: This study revealed that Akt activation is a significant prognostic indicator for OSCC and is correlated with E-cadherin expression. The inhibition of Akt is a possible molecular approach to the treatment of OSCC. | en |
dc.language.iso | en | en |
dc.publisher | British Medical Assoc. | en |
dc.title | Prognostic value of activated Akt expression in oral squamous cell carcinoma. | en |
dc.type | Article | en |
dc.identifier.doi | 10.1136/jcp.2004.024786 | - |
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