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Wound healing effect of silk fibroin/alginate-blended sponge in full thickness skin defect of rat

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Authors
Roh, Dae-Hyun; Kang, Seuk-Yun; Kim, Jeom-Yong; Kwon, Young-Bae; Kweon, Hae Young; Lee, Kwang-Gill; Park, Young-Hwan; Baek, Rong-Min; Heo, Chan-Yeong; Choe, Joon; Lee, Jang-Hern
Issue Date
2006
Publisher
Springer Verlag
Citation
J. Mater. Sci. Mater. Med. 17 (2006) 547
Abstract
Silk fibroin (SF) and alginate (AA) have been proved to be invaluable natural materials in the field of biomedical engineering. This study was designed to compare the wound healing effect of SF, AA and SF/AA-blended sponge (SF/AA) with clinically used Nu GauzeTM (CONT) in a rat full thickness wound model. Two circular skin wounds on the back of rat were covered with either of CONT, SF, AA or SF/AA. On the postoperative days of 3, 7, 10 and 14, residual wound area was calculated, and skin wound tissues were biopsied to measure the area of regenerated epithelium and collagen deposition as well as the number of proliferating cell nuclear antigen (PCNA)-immunoreactive cells. Half healing time (HT50) of SF/AA was dramatically reduced as compared with that of SF, AA or CONT. Furthermore, SF/AA significantly increased the size of re-epithelialization and the number of PCNA positive cells, whereas the effect of SF/AA on collagen deposition was not significantly different as compared with that of SF or AA. These results demonstrate that the wound healing effect of SF/AA is the best among other treatments including SF and AA, and this synergic effect is mediated by re-epithelialization via rapid proliferation of epithelial cell.
ISSN
0957-4530 (print)
1573-4838 (oine)
Language
English
URI
http://hdl.handle.net/10371/6916
DOI
https://doi.org/10.1007/s10856-006-8938-y
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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