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Induction of human umbilical cord blood-derived stem cells with embryonic stem cell phenotypes into insulin producing islet-like structure
Cited 79 time in
Web of Science
Cited 94 time in Scopus
- Authors
- Issue Date
- 2007-01-24
- Publisher
- Elsevier
- Citation
- Biochem Biophys Res Commun 354 (2007) 919-923
- Keywords
- Stem cells ; Human umbilical cord blood ; Islet-like structure differentiation ; Insulin producing cells
- Abstract
- Success in islet-transplantation-based therapies for type I diabetes, coupled with a worldwide shortage of transplant-ready islets, has motivated efforts to develop renewable sources of islet-replacement tissue. Embryonic stem cells (ESCs) have been successfully induced into insulin producing islet-like structure in several studies. However, the source of the ESCs has presented ethical and technical concerns. Here, we isolated a population of stem cells from human cord blood (UCB), which expressed embryo stage specific maker, SSEA-4, and the multi-potential stem cell marker, Oct4. Subsequently, we successfully induced them into insulin-producing islet-like structures, which co-express insulin and C-peptide. These findings might have a significant potential to advance human UCB derived stem-cell-based therapeutics for diabetes.
- ISSN
- 0006-291X
- Language
- English
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