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Regulation of human umbilical cord blood-derived multi-potent stem cells by autogenic osteoclast-based niche-like structure

Cited 9 time in Web of Science Cited 9 time in Scopus
Authors
Sun, Bo; Jeong, Yun-Hyeok; Jung, Ji-Won; Seo, Kwangwon; Lee, Yong Soon; Kang, Kyung-Sun
Issue Date
2007-03-28
Publisher
Elsevier
Citation
Biochem. Biophys. Res. Commun. 357 (2007) 92-98
Keywords
Stem cell nicheUmbilical cord bloodStem cellsOsteoclast
Abstract
Stem cell niches provide the micro-environment for the development of stem cells. Under our culturing regimen, a kind of osteoclast-centralized structure supports the proliferation of MSCs, derived from human cord blood, once they reside on osteoclasts. MSCs in this structure expressed Oct4 which is a marker of embryonic stem cells. Floating daughter cells of MSCs colony showed abilities to differentiate into osteocyte, adipocyte, and neuronal progenitor cells. Compared with the easy senescence of MSCs without this niche-like structure in vitro, these results suggested that osteoclasts might play an important role the development and maintenance of Umbilical cord blood (UCB)-derived MSCs and might provide a means to expand UCB-MSCs in vitro, more easily, through a stem cell niche-like structure.
ISSN
0006-291X
Language
English
URI
http://hdl.handle.net/10371/6958
DOI
https://doi.org/10.1016/j.bbrc.2007.03.072
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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