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Effect of solution properties on nanofibrous structure of electrospun poly(lactic-co-glycolic acid)

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Authors
You, Young; Lee, Seung Jin; Min, Byung-Moo; Park, Won Ho
Issue Date
2006
Publisher
Wiley-Blackwell
Citation
J Appl Polym Sci 2006, 99, 1214–1221
Keywords
electrospinningnanofiberadditivesolution propertiespolyesters
Abstract
Electrospinning of poly(lactic-co-glycolic acid) (PLGA) in chloroform or 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) was investigated, focusing on its solution parameters, to develop nonwoven biodegradable nanofibrous structures for tissue engineering. PLGA nanofibers were obtained by electrospinning of 15 wt % PLGA solution and the resulting average fiber diameters were varied with the range of 270-760 nm, depending on solution property. When small amounts of benzyl triethylammonium chloride (BTEAC) was added to the PLGA/chloroform solution, the average diameter was decreased from 760 to 450 nm and the fibers were densely amounted in a straight shape. In addition, the average fiber diameter (270 nm) of nanofibers electrospun from polar HFIP solvent was much smaller than that (760 nm) of nanofibers electrospun from nonpolar chloroform solvent. Therefore, it could be concluded that conductivity or dielectric constant of the PLGA solution was a major parameter affecting the morphology and diameter of the electrospun PLGA fibers.
ISSN
0021-8995
http://dx.doi.org/10.1002/app.22602
Language
English
URI
http://hdl.handle.net/10371/69596
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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