S-Space College of Dentistry/School of Dentistry (치과대학/치의학대학원) Dept. of Dentistry (치의학과) Journal Papers (저널논문_치의학과)
Mesenchymal stem cell-organized bone marrow elements: an alternative hematopoietic progenitor resource
- Miura, Yasuo; Gao, Zhigang; Miura, Masako; Seo, Byoung-Moo; Sonoyama, Wataru; Chen, WanJun; Gronthos, Stan; Zhang, Li; Shi, Songtao
- Issue Date
- AlphaMed Press
- STEM CELLS 2006;24:2428-2436.
- Mesenchymal stem cell; Hematopoietic stem cell; Platelet-derived growth factor; Bone marrow organ system
- Bone marrow-derived mesenchymal stem cells (BMMSCs) are multipotent postnatal stem cells that have been used for the treatment of bone defects and graft-versus-host diseases in clinics. In this study, we found that subcutaneously transplanted human BMMSCs are capable of organizing hematopoietic progenitors of recipient origin. These hematopoietic cells expressed multiple lineages of hematopoietic cell associated markers and were able to rescue lethally irradiated mice, with successful engraftment in the recipient, suggesting a potential bone marrow (BM) resource for stem cell therapies. Furthermore, we found that platelet-derived growth factor (PDGF) promotes the formation of BMMSC-generated BM niches through upregulation of -catenin, implying that the PDGF pathway contributes to the formation of ectopic BM. These results indicate that the BMMSC-organized BM niche system represents a unique hematopoietic progenitor resource possessing potential clinical value.
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