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Mesenchymal stem cell-organized bone marrow elements: an alternative hematopoietic progenitor resource

Cited 51 time in Web of Science Cited 51 time in Scopus
Authors
Miura, Yasuo; Gao, Zhigang; Miura, Masako; Seo, Byoung-Moo; Sonoyama, Wataru; Chen, WanJun; Gronthos, Stan; Zhang, Li; Shi, Songtao
Issue Date
2006-07
Publisher
AlphaMed Press
Citation
STEM CELLS 2006;24:2428-2436.
Keywords
Mesenchymal stem cellHematopoietic stem cellPlatelet-derived growth factorBone marrow organ system
Abstract
Bone marrow-derived mesenchymal stem cells (BMMSCs) are multipotent postnatal stem cells that have been used for the treatment of bone defects and graft-versus-host diseases in clinics. In this study, we found that subcutaneously transplanted human BMMSCs are capable of organizing hematopoietic progenitors of recipient origin. These hematopoietic cells expressed multiple lineages of hematopoietic cell associated markers and were able to rescue lethally irradiated mice, with successful engraftment in the recipient, suggesting a potential bone marrow (BM) resource for stem cell therapies. Furthermore, we found that platelet-derived growth factor (PDGF) promotes the formation of BMMSC-generated BM niches through upregulation of -catenin, implying that the PDGF pathway contributes to the formation of ectopic BM. These results indicate that the BMMSC-organized BM niche system represents a unique hematopoietic progenitor resource possessing potential clinical value.
ISSN
1549-4918
Language
English
URI
http://hdl.handle.net/10371/69670
DOI
https://doi.org/10.1634/stemcells.2006-0089
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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