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α-Synuclein overexpression reduces gap junctional intercellular communication in dopaminergic neuroblastoma cells

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Authors
Sung, Jee Young; Lee, Hyun Jung; Jeong, Eun Il; Oh, Yohan; Park, Joongkyu; Kang, Kyung-Sun; Chung, Kwang Chul
Issue Date
2007-02-11
Publisher
Elsevier
Citation
Neurosci Lett. 416 (2007) 289-293
Keywords
Parkinson diseaseα-SynucleinGap junctionConnexin-32Cell death
Abstract
α-Synuclein has been implicated in the pathology of certain neurodegenerative diseases, including Parkinson disease (PD) and dementia with Lewy bodies (LBs). Overexpression of human α-synuclein in neuronal cells reduces cell viability, but the precise cellular and molecular mechanisms remain poorly understood. Gap junctional intercellular communication (GJIC) is thought to be essential for maintaining cellular homeostasis and growth control. In the present study, the effect of α-synuclein overexpression on GJIC in human dopaminergic neuroblastoma SH-SY5Y cells was investigated. Cells overexpressing wild-type α-synuclein were more vulnerable to hydrogen peroxide and 6-hydroxydopamine. GJIC was decreased in cells overexpressing α-synuclein. In addition, α-synuclein binds directly to connexin-32 (Cx32). As such, the post-translational modification of Cx32 was enhanced in cells overexpressing α-synuclein. These findings suggest that α-synuclein can modulate GJIC in a dopaminergic neuronal cell line through specific binding to Cx32.
ISSN
0304-3940
Language
English
URI
http://hdl.handle.net/10371/6970
DOI
https://doi.org/10.1016/j.neulet.2007.02.025
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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