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Selenite-induced apoptosis of osteoclasts mediated by the mitochondrial pathway

DC Field Value Language
dc.contributor.authorMin, Byung-Moo-
dc.contributor.authorChung, Youn Wook-
dc.contributor.authorKim, Tae Soo-
dc.contributor.authorLee, Soo Young-
dc.contributor.authorLee, Seoung Hoon-
dc.contributor.authorChoi, Yongwon-
dc.contributor.authorKim, Nacksung-
dc.contributor.authorJeong, Dae-Won-
dc.contributor.authorKim, Ick Young-
dc.date.accessioned2010-09-06-
dc.date.available2010-09-06-
dc.date.issued2006-01-
dc.identifier.citationToxicology Letters 160,143-150en
dc.identifier.issn0378-4274-
dc.identifier.urihttp://hdl.handle.net/10371/69715-
dc.description.abstractThe possible effects of sodium selenite on mature osteoclasts were investigated. Incubation of osteoclast-like cells differentiated from RAW 264.7 cells with sodium selenite induced apoptosis as revealed by morphological changes, internucleosomal DNA fragmentation, and activation of caspase-3. Selenite also induced generation of the superoxide anion and reduced the number of free thiol groups in the osteoclast-like cells, suggestive of a shift to a more oxidizing intracellular environment. In addition, selenite induced protein aggregation by thiol cross-linking, loss of the mitochondrial membrane potential, and cytochrome c release in mitochondria isolated from the osteoclast-like cells. Finally, selenite-induced DNA fragmentation in osteoclasts was inhibited both by cyclosporin A, a blocker of the mitochondrial permeability transition pore, and by DEVD-CHO, a cell-permeable inhibitor of caspase-3. These results thus suggest that selenite induces apoptosis mediated by the mitochondrial pathway in mature osteoclasts.en
dc.language.isoenen
dc.publisherElsevieren
dc.subjectSeleniumen
dc.subjectApoptosisen
dc.subjectOsteoclasten
dc.subjectMitochondriaen
dc.titleSelenite-induced apoptosis of osteoclasts mediated by the mitochondrial pathwayen
dc.typeArticleen
dc.contributor.AlternativeAuthor민병무-
dc.contributor.AlternativeAuthor정영욱-
dc.contributor.AlternativeAuthor김태수-
dc.contributor.AlternativeAuthor이수영-
dc.contributor.AlternativeAuthor이승훈-
dc.contributor.AlternativeAuthor최용원-
dc.contributor.AlternativeAuthor김낙성-
dc.contributor.AlternativeAuthor정대원-
dc.contributor.AlternativeAuthor김익영-
dc.identifier.doi10.1016/j.toxlet.2005.06.019-
Appears in Collections:
College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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