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Systemic administration of minocycline inhibits formalin-induced inflammatory pain in rat

Cited 44 time in Web of Science Cited 47 time in Scopus
Authors
Park, Kyungpyo; Cho, Ik-Hyun; Chung, Young Min; Park, Chul-Kyu; Park, Seong-Hae; Li, Hai Ying; Kim, Donghoon; Piao, Zheng Gen; Choi, Se-Young; Lee, Sung Joong; Kim, Joong Soo; Jung, Sung Jun; Oh, Seog Bae
Issue Date
2006-02
Publisher
Elsevier
Citation
Brain Research 1072, 208-214
Keywords
Formalin testInflammatory painSubstantia gelatinosaMicrogliaMinocycline
Abstract
It has been demonstrated that spinal microglial activation is involved in formalin-induced pain and that minocycline, an inhibitor of microglial activation, attenuate behavioral hypersensitivity in neuropathic pain models. We investigated whether minocycline could have any anti-nociceptive effect on inflammatory pain, after intraperitonial administration of minocycline, 1 h before formalin (5%, 50 μl) injection into the plantar surface of rat hindpaw. Minocycline (15, 30, and 45 mg/kg) significantly decreased formalin-induced nociceptive behavior during phase II, but not during phase I. The enhancement in the number of c-Fos-positive cells in the L4–5 spinal dorsal horn (DH) and the magnitude of paw edema induced by formalin injection during phase II were significantly reduced by minocycline. Minocycline inhibited synaptic currents of substantia gelatinosa (SG) neurons in the spinal DH, whereas membrane electrical properties of dorsal root ganglion neurons were not affected by minocycline. Analysis with OX-42 antibody revealed the inhibitory effect of minocycline on microglial activation 3 days after formalin injection. These results demonstrate the anti-nociceptive effect of minocycline on formalin-induced inflammatory pain. In addition to the well-known inhibitory action of minocycline on microglial activation, the anti-edematous action in peripheral tissue, as well as the inhibition of synaptic transmission in SG neurons, is likely to be associated with the anti-nociceptive effect of minocycline.
ISSN
0006-8993
Language
English
URI
http://hdl.handle.net/10371/69719
DOI
https://doi.org/10.1016/j.brainres.2005.12.039
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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