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Efficacy of sulforaphane is mediated by p38 MAP kinase and caspase-7 activations in ER-positive and COX-2-expressed human breast cancer cells

Cited 17 time in Web of Science Cited 19 time in Scopus
Authors
Jo, Eun-Hye; Kim, Sung-Hoon; Ahn, Nam-Shik; Park, Joon-Suk; Hwang, Jae-Woong; Lee, Yong Soon; Kang, Kyung-Sun
Issue Date
2007
Publisher
Lippincott, Williams & Wilkins
Citation
Eur J Cancer Prev 16:505-510
Keywords
caspase-7chemopreventionhuman breast cancerMAPKsulforaphane
Abstract
Sulforaphane is an antioxidant and a potent stimulator of natural detoxifying enzyme and associated with lowered risk of cancer that is associated with the consumption of cruciferous vegetables. The chemopreventive effects of SFN was investigated using the MCF-7 human breast cancer cells and the M13SV1-immortalized human breast luminal epithelial cells. Sulforaphane reduced proliferation in MCF-7 cells and inhibited cyclooxygenase-2 expression in M13SV1 cells treated with 12-O-tetradecanoylphorbol-13-acetate (TPA). The chemopreventive effects of sulforaphane were associated with p38 mitogen-activated protein kinase suggest its important role in cell survival/apoptosis regulation and stabilization of cyclooxygenase-2. Sulforaphane upregulates p38 in MCF-7 cells and prevented TPA-reduced phosphorylation of p38 in M13SV1 cells, but activated caspase-7 associated with apoptosis in MCF-7 cells. These results suggest that sulforaphane may be an alternative candidate for targeted prevention of ER-positive and cyclooxygenase-2-induced phenotypes and breast cancer.
ISSN
0959-8278 (print)
1473-5709 (online)
Language
English
URI
http://hdl.handle.net/10371/6972
DOI
https://doi.org/10.1097/01.cej.0000243856.97479.3b
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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