SHERP

Biological evaluation of anti-influenza viral activity of semi-synthetic catechin derivatives

Cited 0 time in webofscience Cited 47 time in scopus
Authors
Song, Jae Min; Park, Ki Duk; Lee, Kwang Hee; Byun, Young Ho; Park, Ju Hee; Kim, Sung Han; Kim, Jae-Hong; Seong, Baik Lin
Issue Date
2007-08-01
Publisher
Elsevier
Citation
Antiviral Res. 76, 178-185
Keywords
Influenza virusCatechin derivativesAlkyl chainHemagglutinin
Abstract
Catechin derivatives with different alkyl chain length and aromatic ring substitutions at the 3-hydroxyl group were synthesized from epigallocatechin (EGC) and (+)-catechin (C) and their anti-influenza viral activity were evaluated in vitro and in ovo. Pronounced antiviral activity was observed for derivatives carrying moderate chain length (7–9 carbons) as compared to those with aromatic rings, whereas the 5′-hydroxyl group of the trihydroxy benzyl moiety did not significantly contribute to antiviral activity. The derivatives exerted inhibitory effects for all six influenza subtypes tested including three major types of currently circulating human influenza viruses (A/H1N1, A/H3N2 and B type), H2N2 and H9N2 avian influenza virus. The compounds strongly inhibited adsorption of the viruses on red blood cell (RBC). They also restricted the growth of avian influenza virus in ovo with minimum inhibition concentration (MIC) of 5–10 μM far exceeding the neuraminidase (NA) inhibitor oseltamivir or M2 proton channel inhibitor amantadine. The antiviral activity appears to be mediated by interaction with hemagglutinin (HA)/viral membrane rendering HA less fusogenic at the initial stage of infection. The broad spectrum activity against various subtypes of influenza viruses may complement the limitations of current antivirals and contribute for managing potentially emerging influenza pandemic. The structure-activity data of catechin derivatives may usefully guideline future research endeavors for applying green tea catechins as alternative anti-viral agents.
ISSN
0166-3542
Language
English
URI
http://hdl.handle.net/10371/6985
DOI
https://doi.org/10.1016/j.antiviral.2007.07.001
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse