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Regulation of metal transporters by dietary iron, and the relationship between body iron levels and cadmium uptake

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dc.contributor.authorKim, Dong-Won-
dc.contributor.authorKim, Ki-Young-
dc.contributor.authorChoi, Byung-Sun-
dc.contributor.authorYoun, Pilju-
dc.contributor.authorRyu, Doug Young-
dc.contributor.authorKlaassen, Curtis D.-
dc.contributor.authorPark, Jung-Duck-
dc.date.accessioned2009-08-12T07:28:25Z-
dc.date.available2009-08-12T07:28:25Z-
dc.date.issued2006-10-10-
dc.identifier.citationArch Toxicol 81:327-334en
dc.identifier.issn0340-5761 (print)-
dc.identifier.issn1432-0738 (online)-
dc.identifier.urihttp://hdl.handle.net/10371/7028-
dc.description.abstractIron (Fe) plays essential roles in biological processes, whereas cadmium (Cd) is a toxic and non-essential metal. Two metal transporters, divalent metal transporter 1 (DMT1) and metal transporter protein 1 (MTP1), are responsible for Fe transport in mammals. Here, we studied the effect of dietary Fe on the expression of these metal transporters in peripheral tissues, and the uptake by these tissues of Cd. Mice were fed an Fe-sufficient (FeS: 120 mg Fe/kg) or Fe-deficient (FeD: 2–6 mg Fe/kg) diet for 4 weeks. The total Fe levels in the body were evaluated by measuring tissue Fe concentrations. Tissue Cd concentrations were determined 24 h after the mice received a single oral dose of Cd. Animals fed a FeD diet showed depletion of body Fe levels and accumulated 2.8-fold higher levels of Cd than the FeS group. Quantitative real time RT-PCR revealed that whereas DMT1 and MTP1 were both ubiquitously expressed in all FeS peripheral tissues studied, DMT1 was highly expressed in brain, kidney, and testis, whereas MTP1 was highly expressed in liver and spleen. Depletion of the body Fe stores dramatically upregulated DMT1 and MTP1 mRNA expression in the duodenum as well as moderately upregulating their expression in several other peripheral tissues. The iron response element positive isoform of DMT1 was the most prominently upregulated isoform in the duodenum. Thus, DMT1 and MTP1 may play an important role in not only maintaining Fe levels but also facilitating the accumulation of Cd in the body of mammals.en
dc.description.sponsorshipThis work was supported by grant No. R01-2004-000-10584-0 from the Basic Research Program of the Korea Science and Engineering Foundation.en
dc.language.isoen-
dc.publisherSpringer Verlagen
dc.subjectIron (Fe)en
dc.subjectCadmium (Cd)en
dc.subjectDivalent metal transporter 1 (DMT1)en
dc.subjectMetal transporter protein 1 (MTP1)en
dc.subjectDuodenumen
dc.titleRegulation of metal transporters by dietary iron, and the relationship between body iron levels and cadmium uptakeen
dc.typeArticleen
dc.contributor.AlternativeAuthor김동원-
dc.contributor.AlternativeAuthor김기영-
dc.contributor.AlternativeAuthor최병선-
dc.contributor.AlternativeAuthor윤필주-
dc.contributor.AlternativeAuthor류덕영-
dc.contributor.AlternativeAuthor박정덕-
dc.identifier.doi10.1007/s00204-006-0160-7-
Appears in Collections:
College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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