급성 백혈병 환아의 피문(Dermatoglyphics)에 관한 연구

Abstract

There have been a number of apparently conflicting studies on the dermatoglyphics of children with leukemia. Some investigators reported statistically significant differences in dermal pattern frequencies and suggested dermatoglyphic findings are valuable in identifying individuals with increased risk of leukemia. In contrast, other workers believed that dermatog Iyphic abnormalities of leukemic patients had no diagnostic significance. Since all of these findings were obtained on Caucasian populations and it is well known fact that there are racial differences in dermatoglyphic patterns the present study was undetaken to survey derrnatog lyphics of leukemic children and compare with those of normal controls residing in this region. The subjects studied include 30 children (IS boys and 15 girls) with acute leukemia, 28 mothers of patients and 30 normal control children of similar age and sex. The patients ranged in age from 7 months to 12 years. The diagnosis of acute leukemia was confirmed by bone marrow biopsy in all patients at the first admission to the Pediatric Ward of Sso rl National University Hospital between July 1973 to December 1975. The following parameters were examined: dermal patterns of distal phalanges of digits (whorls, ulnar loops, radial loops, and arches); digital pattern intensity indcies: palmar flexion creases (normal, complete and partial simian lines, and Syndney line); hypothenar, thenar/I-, 1,-, I" -1.- and hallucal- area patterns; axial triradius (proximal and distal); and presence or absence of clinodactyly of little fingers. The data were statistically analysed by means of the x' and Student's t tests. The dermal patterns of digits in children with acute leukemia did not differ those of normal control children. The mothers of patients, however, had significantly more arches on their fingers (7.1%). There was also no difference in digital pattern intensity indicies in three groups. There was definite increase in incidence (40.0%) of anomalous palmar flexion creases (complete and partial simian lines) in children with acute leukemia. Frequencies of simian lines in the normal control children and mothers of leukemic children were 13.3% and 7.1%, respectively. Sydney line was not observed in all three groups. Evaluation of dermal pattern frequencies in hypothenar-, thenar/I-,I,-, 1,-, 1,- and hallucal-area showed no significant differences in the patients, mothers, and control groups. Incidences of axial triradius (proximal and distal) and clinodactyly likewise revealed no difference. The results suggested that dermatoglyphic analysis may not be a useful diagnostic aid in identifying individuals who have increased constitutional susceptibility to leukemogenesis.