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구서제 RH-787(N-3-Pyridylmethyl-N-p-nitrophenylurea)이 췌도에 미치는 영향
Effect of Rodenticide, RH-787, on Islets of Pancreas Report of an Autopsy Case andExperimenal Appraisal-

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Authors
박성회; 김용일; 안긍환; 이상국; 윤광선; 민훈기
Issue Date
1976-12
Publisher
서울대학교 의과대학
Citation
Seoul J Med 1976;17(4):415-419
Abstract
RH-787 (N -S-pvridy1methy1-N' <p-nitrophenylurea), a
rodenticide, has been used in Korea since 1976 with
subsequent increasing incidence of its human intoxication
for the purpose of comitting suicide, but the
pathogenesis of this drug-induced diabetes mellitus
remains inconclusive. The authors herein presents an
autopsy case of a 40-year-old female whose clinical
course was reflected by a selective involvement of
pancreatic islets as a target organ. p·cell cytolysis and loss of its granularity comprised a major pathologic
alteration.
To support and clarify the pathologic characteristics
of the above autopsy case, an animal 'experiment was
carried out by means of inducing acute RH-787 intoxication
in rats. In animal group fed with 72.0 mg/kg
(MLD,o x 4) the blood sugar levels before death elevated
2~3 times (up to 378 mg%) of control group
and died within 24 hours, but in the other group with
1/3 of MLD50 for 2 times, its average elevation ranged
136~180mg%. Pancreatic lesions were basically
identical to those seen in the autopsy case. featuring
complete degranulation of p·cells or their cytolysis in
Langerhans islets.
It is of authors assumption that RH-787 affects
selectively p-cells of pancreatic islets with similar
mechanism to streptozotocin, resulting in acute hyperglycemic
course.
Language
Korean
URI
http://hdl.handle.net/10371/7197
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Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 17 No.4 (1976)
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