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구서제 RH-787(N-3-Pyridylmethyl-N-p-nitrophenylurea)이 췌도에 미치는 영향 : Effect of Rodenticide, RH-787, on Islets of Pancreas Report of an Autopsy Case andExperimenal Appraisal-
DC Field | Value | Language |
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dc.contributor.author | 박성회 | - |
dc.contributor.author | 김용일 | - |
dc.contributor.author | 안긍환 | - |
dc.contributor.author | 이상국 | - |
dc.contributor.author | 윤광선 | - |
dc.contributor.author | 민훈기 | - |
dc.date.accessioned | 2009-08-14T06:16:09Z | - |
dc.date.available | 2009-08-14T06:16:09Z | - |
dc.date.issued | 1976-12 | - |
dc.identifier.citation | Seoul J Med, Vol.17 No.4, pp. 415-419 | - |
dc.identifier.issn | 0582-6802 | - |
dc.identifier.uri | https://hdl.handle.net/10371/7197 | - |
dc.description.abstract | RH-787 (N -S-pvridy1methy1-N' rodenticide, has been used in Korea since 1976 with
subsequent increasing incidence of its human intoxication for the purpose of comitting suicide, but the pathogenesis of this drug-induced diabetes mellitus remains inconclusive. The authors herein presents an autopsy case of a 40-year-old female whose clinical course was reflected by a selective involvement of pancreatic islets as a target organ. p·cell cytolysis and loss of its granularity comprised a major pathologic alteration. To support and clarify the pathologic characteristics of the above autopsy case, an animal 'experiment was carried out by means of inducing acute RH-787 intoxication in rats. In animal group fed with 72.0 mg/kg (MLD,o x 4) the blood sugar levels before death elevated 2~3 times (up to 378 mg%) of control group and died within 24 hours, but in the other group with 1/3 of MLD50 for 2 times, its average elevation ranged 136~180mg%. Pancreatic lesions were basically identical to those seen in the autopsy case. featuring complete degranulation of p·cells or their cytolysis in Langerhans islets. It is of authors assumption that RH-787 affects selectively p-cells of pancreatic islets with similar mechanism to streptozotocin, resulting in acute hyperglycemic course. | - |
dc.language.iso | ko | - |
dc.publisher | 서울대학교 의과대학 | - |
dc.title | 구서제 RH-787(N-3-Pyridylmethyl-N-p-nitrophenylurea)이 췌도에 미치는 영향 | - |
dc.title.alternative | Effect of Rodenticide, RH-787, on Islets of Pancreas Report of an Autopsy Case andExperimenal Appraisal- | - |
dc.type | SNU Journal | - |
dc.contributor.AlternativeAuthor | Park, Song Hoi | - |
dc.contributor.AlternativeAuthor | Kim, Yong Il | - |
dc.contributor.AlternativeAuthor | Ahn, Geung Hwan | - |
dc.contributor.AlternativeAuthor | Lee, Sang Kook | - |
dc.contributor.AlternativeAuthor | Yun, Kwang Sun | - |
dc.contributor.AlternativeAuthor | Min, Hun Ki | - |
dc.citation.journaltitle | 서울 의대 잡지 | - |
dc.citation.journaltitle | 서울 의대 학술지 | - |
dc.citation.journaltitle | Seoul Journal of Medicine | - |
dc.citation.endpage | 419 | - |
dc.citation.number | 4 | - |
dc.citation.pages | 415-419 | - |
dc.citation.startpage | 415 | - |
dc.citation.volume | 17 | - |
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