태아 및 흰쥐의 흉선에서 비만세포의 발달에 관한 연구
Studies on the Development of Mast Cells in the Thymuses of the Human Fetuses and Rats

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서울대학교 의과대학
Seoul J Med 1979;20(1):20-26
Human fetal thymuses and thymuses of the fetal
and neonatal rats were resected to study the changes
of the mast cells with maturation by the observation
of the stainability. number. shape and distribution of
the human mast cells and comparing it with those of the rat.
The resected thymuses stained wilh Periodic AcidSchiff
(PAS), Alcian Blue-Safranin (ABS), Toluidine
Blue (TB) and Methyl Green-Pyronin (MGP) were
observed under the light microscope and the following
results were obtained.
1. Mast cells were obseved first on the 4th month
of gestation in the human fetuses and on the 16th day
of gestation in the rat fetuses.
2. A few mast cells were stained with TB with
weak metachromasia after 5th month of gestation in
the human fetuses but numerous mast cells were
stained with TB with strong metachromasia after 19th
day of gestation in the rat fetuses, so it seems that
the maturation time of human mast cells is retarded
than that of the rat mast cells.
3. The number of mast cells per unit area increased
with increasing age and peaked on the 8th month,
but there was almost no change after that time until
10th month in the human fetuses.
4. The mast cells were oval, round or spindle shaped
in the order of frequency and oval shaped mast
cells were observed more frequently than the round
shaped cells with increasing age in the human fetuses.
5. The mast cells were more numerous in the parenchyme
than in the interlobular septum and the
number of mast cells decreased in the parenchyme
and increased in the interlobular septum with increasing
age in the human fetuses, and immature mast
cells stained with PAS or AB were observed mainly
in the parenchyme and mature mast cells stained with
TB or MGP were observed mainly in the interlobularseptum
in the rat.
6. From the above results it is thought that there
was much differences in the maturation time and
stainability of mast cells, and the distribution of mast
cells suggests that mast cells may be originated from
the lymphocyts.
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 20 No.1 (1979)
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