태아 및 흰쥐의 흉선에서 비만세포의 발달에 관한 연구

Abstract

Human fetal thymuses and thymuses of the fetal and neonatal rats were resected to study the changes of the mast cells with maturation by the observation of the stainability. number. shape and distribution of the human mast cells and comparing it with those of the rat. The resected thymuses stained wilh Periodic AcidSchiff (PAS), Alcian Blue-Safranin (ABS), Toluidine Blue (TB) and Methyl Green-Pyronin (MGP) were observed under the light microscope and the following results were obtained. 1. Mast cells were obseved first on the 4th month of gestation in the human fetuses and on the 16th day of gestation in the rat fetuses. 2. A few mast cells were stained with TB with weak metachromasia after 5th month of gestation in the human fetuses but numerous mast cells were stained with TB with strong metachromasia after 19th day of gestation in the rat fetuses, so it seems that the maturation time of human mast cells is retarded than that of the rat mast cells. 3. The number of mast cells per unit area increased with increasing age and peaked on the 8th month, but there was almost no change after that time until 10th month in the human fetuses. 4. The mast cells were oval, round or spindle shaped in the order of frequency and oval shaped mast cells were observed more frequently than the round shaped cells with increasing age in the human fetuses. 5. The mast cells were more numerous in the parenchyme than in the interlobular septum and the number of mast cells decreased in the parenchyme and increased in the interlobular septum with increasing age in the human fetuses, and immature mast cells stained with PAS or AB were observed mainly in the parenchyme and mature mast cells stained with TB or MGP were observed mainly in the interlobularseptum in the rat. 6. From the above results it is thought that there was much differences in the maturation time and stainability of mast cells, and the distribution of mast cells suggests that mast cells may be originated from the lymphocyts.