S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Medicine (의학과) The Seoul Journal of Medicine The Seoul Journal of Medicine Vol. 20 No.2 (1979)
일부 무의촌지역과 도시에서 분리한 S. pneumoniae의 항균제 감수성에 관한 연구
Studies on the Antimicrobic Susceptibility of S. Pneumoniae isolated from Doctorless areas and Seoul.
- 김익상; 장우현; 이광호; 신희섭; 차장용; 이성훈; 임정규
- Issue Date
- 서울대학교 의과대학
- Seoul J Med, Vol.20 No.2, pp. 82-91
- 64 strains of S. pneumoniae isolated from the residents
of doctorless areas in Korea from Aug. 1976 to
Jan. 1977 and 62 strains of S. pneumoniae isolated
from the children in Seoul at Mar, 1977 were examined
for susceptibility to 14 antimicrobics by agar dilution method.
The susceptibility of two groups to each antimicrohies
were compared and incidence of resistant strains
in each antimicrobics and correlation in the
antimicrobic susceptibility of 126 strains of
S. pneumoniae among 14 antimicrobics were analyzed.
1. The mean MIC's of Carbenicillin and Kanamycin
to the S. pneumoniae isolated from Seoul were 9.8
and 1. 7 times higher than those to the S. pneumoniae
isolated from doctoress areas respectively.
2. There were no significant differences in susceptibility
to Penicillin, Ampicillin, Cephalexin, Tetracycline,
Oxytetracycline. Doxycycline, Minocycline,
Gentamicin, Streptomycin, Erythromycin, Cotrimoxazole,
and Troleandomycin respectively between S.
pneumoniae isolated from doctorless areas and Seoul.
3. Incidence of resistant strains in S. pneumoniae
isolated from doctorless areas was the highest with
KanamycinC79.7%) followed by TetracyclineC73. 3%),
Oxytetracycline(67.2%), Streptomycin(48.4%) Doxycycline(
42.0%) Minocycline(31. 3%), Gentamicin
(28.1%), Carbenicillin (4. 7%) CotrimoxzoleC3.1%),
Troleandomycin(I. 6%), and Cephalexin(I. 6%).
There were no strains resistant to Penicillin.
Ampicillin, or Erythromycin.
4. Incidence of resistant strains in S. pneumoniae
isolated from Seoul was the highest with Kanamycin
(90.3%). followed by Tetracyc1ine(87.0%) CarbenicillinC74.2%),
Oxytetracyc1ineC66. 2%), Streptomycin
(61. 3%), Minocycline(33.8%), Gentamicin (24. 2%),
and Doxycycline(3. 2%).
There were no strains resistant to Penicillin, Ampicillin,
Cephalexin, Cotrimoxazole, or Troleandomycin.
5. There were significant differences in the incidence
of resistant strains between two groups of S.
pneumoniae with Carbenicillin and Doxycycline.
6. There were high correlation in susceptibility of
126 strains of S. pneumoniae among Tetracyline,
Oxytetracycline. Doxycycline and Minocyclnet correlation
coefficient ranged between 0.86 to 0.95), but
there were no significant correlation in susceptibility
of S. pneumoniae among Penicillin, Ampicillin, Carbenicillin,
and Cephalexin(correlation coefficient ranged
between O. 01 to O. 38). Correlation coeffieient of susce-ptibility of S. pneumoniae between Kanamycin and
Streptomycin was 0.68.