한국인 위암환자에서 항원 분포에 관한 연구

Abstract

Even though the HL-A antigens as the major histocompatibility antigens have been contributing an important role in the immunological aspect of the clinical transplantation. and recently considerable attentions are focusing on the possible association of various disease or malignant disease with the certain HL-A specifities, any datas for the distribution of the HL-A antigens in Korean population and the HL-A serotyping for the kidney transplant is not available at present time. This present report is a studies on the HL-A antigens distribution among 155 normal Korean population and 76 gastric cancer patients with the method of Boyum's lymphocyte isolation technic with Ficoll and Isopaque mixture and the method of Terasaki's microlymphocytotoxicity test with 29 NIH standard antisera for 16 HL-A specificities at Seoul National University Hospital. The results are as following; 1. The HL-A antigens are rather evenly distributed throughout the first and second series in both normal Koreans and gastric cancer patient which is a good evidence of diversity in the polymorphism of HL-A antigens. 2. The most frequent HL-A antigens are HL-A 2,13.12 and 10 in normal control group. and HL-A 10.5.2 and 13 in gastric cancer patient. HL-A 9 is rather infrequent compared to other Oriental populations, and HL-A 1 which has heen recognized to be absent from Orientals occurs 17.4%. 3. It is interesting findings that in gastric cancer group HL~A 10 from first sublocus and 5 from second sublocus are markedly increased than normal control group and HL-A 11 from first sublocus and 12 from second sublocus are markedly decreased than normal control group. The author strongly feels that . additional study to confirm the above findings should be done. 4. There is a relatively large proportion of blank alleles: 24% (first series) and 15% (second series) in normal control group, and 22% (first series) and 15% (second series) in gastric cancer group, which seems to be related to the limited number of antisera and the limited number of serum panels used in this study, and related to the probable existence of unknown specifities in OUf native Korean population.