급성 일산화탄소 중독시의 소장운동과 흡수기능

Abstract

Adult rabbits were exposed to carbon monoxide. 1.000ppm or 3.000ppm. and the motility of the ileum and the absorptive function were studied. The motility was expressed in terms of the frequency of the peristalsis and the amplitude of the peristaltic wave. A test solution was put in the intestinal loop made in the ileum, and the decreases in the components of the solution were measured in the samples taken after 30 minutes period. The test solution contained urea and sodium ion which were subjected to passive or active transport, respectively. As a marker substance for the volume measurement, polyethylene glycol was added in the solution, too. One hour after the insertion of the tracheal canule, the first trial was performed, that was the test solution was placed in the loop, leaving it for 30 minutes. after which the final sample was obtained for the purpose of analysis. It was the experiment of period I. Following the period I. the animal was exposed to the carbon monoxide for 90minutes except in the control group. after which same trial was performed as in the period I. This period of inhalation of carbon monoxide was denoted as the period n. In the period ill, carbon monoxide containing gas was replaced by fresh air. otherwise the experimental procedure was same as in period I or H. The control experiments were composed of the same procedure as above. except using carbon monoxide in the period H. They followed the time schedule of the experiments in which carbon monoxide was used. In the control experiments. deteriorations in the physiological parameters including the intestinal function were noticed as the time elapsed even in the absence of carbon monoxide. Animals faced long standing adverse conditions other than carbon monoxide inhalation would suffer from the impairment of functions. Therefore, the results obtained in the experimental groups were compared with those of the same period of the control group. The results obtained were as follows; 1. The oxygen content of the arterial blood subjected to 1. OOOppm or 3.000ppm carbon monoxide was 10.6 vol. % or 8.8 vol. %. respectively. They rose to 14.8 vol. % or 13.5 vol. % when the inhaled gas was replaced by fresh air. 2. Although slight degree of slowing in the heart rate and drop in the mean arterial blood pressure were revealed, there was little consistent influence upon the circulatory function. 3. Slight increase in the frequency of the peristaltic waves was noticed when the noxious gas was given. The tension developed in the longitudinal direction of the small intestine was markedly dropped by the 1. 000 ppm of carbon monoxide. However. occasionally strong peristaltic waves predominated in the cases of 3.000ppm. 4. The absorption of sodium ion was impaired by the exposure to carbon monoxide. and the recovery was not completed in the course of fresh air inhalation up to 2 hours. On the contrary. the absorption of urea suffered little influences. 5. The volume of the intestinal loop increased in .the case of high concentration of carbon monoxide. and it seemed to be related to the deterioration of the active absorption process. 6. The results were reviewed from the point of view of clinical signs. such as diarrhea. encountered not rarely in carbon monoxide poisoning.