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Triple-negative, basal-like, and quintuple-negative breast cancers: better prediction model for survival

Cited 45 time in Web of Science Cited 44 time in Scopus
Authors
Choi, Yoon-La; Oh, Ensel; Park, Sarah; Kim, Yeonju; Park, Yeon-Hee; Song, Kyoung; Cho, Eun Yoon; Hong, Yun-Chul; Choi, Jong Sun; Lee, Jeong Eon; Kim, Jung Han; Nam, Seok Jin; Im, Young-Hyuck; Yang, Jung-Hyun; Shin, Young Kee
Issue Date
2010-09
Publisher
BioMed Central
Citation
BMC Cancer; Vol.10; 507
Abstract
Background: Triple-negative breast cancers (TNBCs) and basal-like breast cancers (BLBCs) are known as poor outcome subtypes with a lack of targeted therapy. Previous studies have shown conflicting results regarding the difference of prognostic significance between TNBCs and BLBCs. In this study, we aimed to characterize the
prognostic features of TNBCs, in view of BLBCs and quintuple-negative breast cancers (QNBC/5NPs).
Methods: Using tissue microarray-based immunohistochemical analysis, we categorized 951 primary breast cancers
into four or five subtypes according to the expression of ER, PR, HER2, and basal markers (CK5/6, EGFR).
Results: The results of this study showed that both TNBCs and BLBCs were associated with high histological and/
or nuclear grades. When the TNBCs are divided into two subtypes by the presence of basal markers, the clinicopathologic characteristics of TNBCs were mainly maintained in the BLBCs. The 5-subgrouping was the better prediction model for both disease free and overall survival in breast cancers than the 4-subgrouping. After
multivariate analysis of TNBCs, the BLBCs did not have a worse prognosis than the QNBC/5NPs. Interestingly, the patients with BLBCs showed significant adjuvant chemotherapy benefit. In addition, QNBC/5NPs comprised about 6~8% of breast cancers in publicly available breast cancer datasets
Conclusion: The QNBC/5NP subtype is a worse prognostic subgroup of TNBCs, especially in higher stage and this result may be related to adjuvant chemotherapy benefit of BLBCs, calling for caution in the identification of
subgroups of patients for therapeutic classification.
ISSN
1471-2407
Language
English
URI
http://hdl.handle.net/10371/73428
DOI
https://doi.org/10.1186/1471-2407-10-507
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College of Pharmacy (약학대학)Dept. of Pharmacy (약학과)Journal Papers (저널논문_약학과)
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