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Triple-negative, basal-like, and quintuple-negative breast cancers: better prediction model for survival

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dc.contributor.authorChoi, Yoon-La-
dc.contributor.authorOh, Ensel-
dc.contributor.authorPark, Sarah-
dc.contributor.authorKim, Yeonju-
dc.contributor.authorPark, Yeon-Hee-
dc.contributor.authorSong, Kyoung-
dc.contributor.authorCho, Eun Yoon-
dc.contributor.authorHong, Yun-Chul-
dc.contributor.authorChoi, Jong Sun-
dc.contributor.authorLee, Jeong Eon-
dc.contributor.authorKim, Jung Han-
dc.contributor.authorNam, Seok Jin-
dc.contributor.authorIm, Young-Hyuck-
dc.contributor.authorYang, Jung-Hyun-
dc.contributor.authorShin, Young Kee-
dc.date.accessioned2011-06-16T05:33:02Z-
dc.date.available2011-06-16T05:33:02Z-
dc.date.issued2010-09-
dc.identifier.citationBMC Cancer; Vol.10; 507en
dc.identifier.issn1471-2407-
dc.identifier.urihttp://hdl.handle.net/10371/73428-
dc.description.abstractBackground: Triple-negative breast cancers (TNBCs) and basal-like breast cancers (BLBCs) are known as poor outcome subtypes with a lack of targeted therapy. Previous studies have shown conflicting results regarding the difference of prognostic significance between TNBCs and BLBCs. In this study, we aimed to characterize the
prognostic features of TNBCs, in view of BLBCs and quintuple-negative breast cancers (QNBC/5NPs).
Methods: Using tissue microarray-based immunohistochemical analysis, we categorized 951 primary breast cancers
into four or five subtypes according to the expression of ER, PR, HER2, and basal markers (CK5/6, EGFR).
Results: The results of this study showed that both TNBCs and BLBCs were associated with high histological and/
or nuclear grades. When the TNBCs are divided into two subtypes by the presence of basal markers, the clinicopathologic characteristics of TNBCs were mainly maintained in the BLBCs. The 5-subgrouping was the better prediction model for both disease free and overall survival in breast cancers than the 4-subgrouping. After
multivariate analysis of TNBCs, the BLBCs did not have a worse prognosis than the QNBC/5NPs. Interestingly, the patients with BLBCs showed significant adjuvant chemotherapy benefit. In addition, QNBC/5NPs comprised about 6~8% of breast cancers in publicly available breast cancer datasets
Conclusion: The QNBC/5NP subtype is a worse prognostic subgroup of TNBCs, especially in higher stage and this result may be related to adjuvant chemotherapy benefit of BLBCs, calling for caution in the identification of
subgroups of patients for therapeutic classification.
en
dc.language.isoenen
dc.publisherBioMed Centralen
dc.titleTriple-negative, basal-like, and quintuple-negative breast cancers: better prediction model for survivalen
dc.typeArticleen
dc.contributor.AlternativeAuthor최윤라-
dc.contributor.AlternativeAuthor오은설-
dc.contributor.AlternativeAuthor박사라-
dc.contributor.AlternativeAuthor김연주-
dc.contributor.AlternativeAuthor박연희-
dc.contributor.AlternativeAuthor송경-
dc.contributor.AlternativeAuthor조은윤-
dc.contributor.AlternativeAuthor홍윤철-
dc.contributor.AlternativeAuthor최종선-
dc.contributor.AlternativeAuthor이정언-
dc.contributor.AlternativeAuthor김정한-
dc.contributor.AlternativeAuthor남석진-
dc.contributor.AlternativeAuthor임영혁-
dc.contributor.AlternativeAuthor양정현-
dc.contributor.AlternativeAuthor신영기-
dc.identifier.doi10.1186/1471-2407-10-507-
Appears in Collections:
College of Pharmacy (약학대학)Dept. of Pharmacy (약학과)Journal Papers (저널논문_약학과)
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