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A Study of the in Vitro Effect of L-Asparaginase, EC-l and EC-2, on the Glycine and Nucleic Acid Contents in Regenerating Liver of Albino Rats

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Authors
조경해
Issue Date
1974-12
Publisher
서울대학교 의과대학
Citation
Seoul J Med 1974;15(4):257-269
Abstract
Two Lvasparagtnases, designated EC-l and
EC-2. have been partially purified from E.
coli 0112a. and incubated respectively with the
homogenates of the regenerating liver tissues
of albino rats at 24 and 48hr. after partial
hepatectomy. with the following conclusion.
(1) EC-2 exerts in vitro an effect to lower
the nucleic acid contents in the regenerating
liver homogenate. while EC-l does not.
(2) EC-2 also lowers the content of glycine
in the regenerating tissue homogenate. while
EC-l does not.
With the above results. possible mechanisms
were discussed regarding the mitotic arrest
selectively displayed by EC-2.
Language
English
URI
http://hdl.handle.net/10371/7374
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 15 No.4 (1974)
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