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Expression of Sonic hedgehog signaling molecules in normal,hyperplastic and carcinomatous endometrium

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Authors
Kim, Seok-Hyung; Shin, Young Kee; Kim, Kyung Hee; Kim, Jin Man; Choi, Yoon-La; Lee, Ho-chang; Seong, In Ock; Kim, Bum Kyung; Chae, Seoung Wan; Chung, Yun-Shin
Issue Date
2009-05-01
Publisher
Wiley-Blackwell;
Japanese Society of Pathology
Citation
Pathology International 2009; 59: 279–287
Keywords
adenocarcinoma,endometrium
Abstract
The aim of the present study was to determine the expression
profile of the hedgehog (Hh) signaling molecules
in normal, hyperplastic, and carcinomatous uterine
endometrium. For this purpose, 271 endometrial tissue
samples, (62 of normal endometrium, 127 of endometrial
hyperplasias, and 82 endometrial adenocarcinomas) were
studied using antibodies recognizing Hh-related signaling
proteins, such as, sonic hedgehog (Shh), Patched (PTCH),
Smoothened (Smo), Suppressor of fused [Su(Fu)], Gli-1,
Gli-2, and Gli-3 by immunohistochemistry. The mRNA
expression of these molecules was also assessed on
reverse transcription–polymerase chain reaction. In the
normal endometrium, the expression of Hh signaling molecules
was generally downregulated except for Su(Fu),
Gli-2, and Shh. In particular, the expression of both PTCH
and Smo was very low or almost absent. Overall expression
of Hh signaling molecules increased in hyperplastic
endometrium; in particular, PTCH and Smo were significantly
highly expressed in complex and atypical hyperplasia.
In carcinoma samples extensive alterations were
observed in the expression pattern of the signaling molecules.
Nuclear Gli-2, cytoplasmic Gli-3, and Su(Fu) were
overexpressed, whereas Shh, PTCH, and Smo expression
were significantly reduced compared with the hyperplastic
endometrium. The results suggest that the alteration of Hh
signaling may be implicated in tumorigenesis of the
endometrium.
ISSN
1320-5463 (print)
1440-1827 (online)
Language
English
URI
http://hdl.handle.net/10371/7387
DOI
https://doi.org/10.1111/j.1440-1827.2009.02366.x
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College of Pharmacy (약학대학)Dept. of Pharmacy (약학과)Journal Papers (저널논문_약학과)
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