Publications
Detailed Information
The antibacterial and immunostimulative effect of chitosan-oligosaccharides against infection by Staphylococcus aureus isolated from bovine mastitis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Moon, Jin-San | - |
dc.contributor.author | Kim, Hee-Kyung | - |
dc.contributor.author | Koo, Hye Cheong | - |
dc.contributor.author | Joo, Yi-Seok | - |
dc.contributor.author | Nam, Hyang-mi | - |
dc.contributor.author | Park, Yong Ho | - |
dc.contributor.author | Kang, Mun-Il | - |
dc.date.accessioned | 2009-08-20T09:36:10Z | - |
dc.date.available | 2009-08-20T09:36:10Z | - |
dc.date.issued | 2007-03-15 | - |
dc.identifier.citation | Appl Microbiol Biotechnol 75:989-998 | en |
dc.identifier.issn | 0175-7598 (print) | - |
dc.identifier.issn | 1432-0614 (online) | - |
dc.identifier.uri | https://hdl.handle.net/10371/7390 | - |
dc.description.abstract | Based on our previous study evaluating the in vivo cure efficacy of chitosan on bovine mastitis, a more water-soluble chitosan-oligosaccharide (OCHT) with a high degree of deacetylation and low molecular weight was prepared to obtain high antibiotic efficacy. The growth of Staphylococcus aureus isolated from bovine mastitis was inhibited within 10 min of treatment with OCHT in concentrations ranging from 0.0001 to 0.5%. Additionally, electron microscopic observation indicated that the surface of the OCHT-treated bacteria was expanded, distorted, and lysed compared to that of the control bacteria. In mice, the proportion of monocytes was elevated, and the levels of interleukin-6 and interferon-γ sharply increased l h after the peritoneal inoculation of the OCHT (0.5 to 1 mg per mouse). Mice challenged intraperitoneally with S. aureus (2.5 × 108 colony forming units) after oral treatment with OCHT (0.5 to 2 mg per day) for 7 days showed a higher survival rate (70–100%) than that of the control (10%). We suggest that the OCHT prepared in this study is a potential agent for the prevention and treatment of bovine mastitis based on its strong antibacterial activity against S. aureus as well as the immunostimulative effect it exhibits on murine infection by S. aureus. | en |
dc.description.sponsorship | This work was supported by a grant from the
National Veterinary Research and Quarantine Services, Republic of Korea. Dr.Hye CheongKoo andDr.YongHo Park were supported by the Korea Research Foundation Grant (KRF-2006-005-J02903), the Technology Development Program for Agriculture and Forestry provided by the Ministry of Agriculture and Forestry (grant no. 305003031HD110), and the Research Institute of Veterinary Science, Department of Veterinary Microbiology, College of Veterinary Medicine and the BK21 Program for Veterinary Science, Seoul National University. | en |
dc.language.iso | en | - |
dc.publisher | Springer Verlag | en |
dc.subject | Chitosan-oligosaccharides | en |
dc.subject | Staphylococcus aureus | en |
dc.subject | Antibacterial activity | en |
dc.subject | Immunostimulative effect | en |
dc.title | The antibacterial and immunostimulative effect of chitosan-oligosaccharides against infection by Staphylococcus aureus isolated from bovine mastitis | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 문진산 | - |
dc.contributor.AlternativeAuthor | 김희경 | - |
dc.contributor.AlternativeAuthor | 구혜정 | - |
dc.contributor.AlternativeAuthor | 주이석 | - |
dc.contributor.AlternativeAuthor | 남향미 | - |
dc.contributor.AlternativeAuthor | 박용호 | - |
dc.contributor.AlternativeAuthor | 강문일 | - |
dc.identifier.doi | 10.1007/s00253-007-0898-8 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.