Publications

Detailed Information

구강 편평세포암종에서 Vascular Endothelial Growth Factor 발현과 미세혈관 밀도 : VEGF Expression and Microvessel Density in Oral Squamous Cell Carcinomas

DC Field Value Language
dc.contributor.author임지준-
dc.contributor.author홍삼표-
dc.contributor.author이재일-
dc.contributor.author홍성두-
dc.contributor.author임창윤-
dc.date.accessioned2011-10-13T01:04:53Z-
dc.date.available2011-10-13T01:04:53Z-
dc.date.issued2000-
dc.identifier.citationKorean J Pathol 2000;34:190-8en
dc.identifier.issn1738-1843-
dc.identifier.urihttps://hdl.handle.net/10371/74076-
dc.description.abstractAngiogenesis is an essential process in tumor growth and metastasis. VEGF has been considered a leading candidate inducing tumor angiogenesis. VEGF expression was significantly correlated with clinical stage, lymph node matastasis, and prognosis of cancers of various parts of body. However, little has been known about the correlation between VEGF expression and clinicopathologic parameters in oral squamous cell carcinoma. The aim of this study was to correlate VEGF expression with the clinicopathological parameters and microvessel density. Forty six oral squamous cell carcinomas were analyzed using immunohistochemical method with primary antibodies to VEGF and CD31. VEGF expression was detected in 33 (71.7%) of the 46 cases. The microvessel density was significantly correlated with VEGF expression (P=0.002). There was no correlation between microvessel density and tumour size, clinical stage, and lymph node metastasis, respectively. VEGF expression did not correlate with the histological grade of tumour differentiation, tumour size, and clinical stages. The VEGF-positive rate seemed to be higher in patients with cervical lymph nodal metastasis than in those without it, but it was not statistically significant. In conclusion, the overexpression of VEGF in the oral squamous cell carcinoma seemed to be associated with a more aggressive course of the disease. Further study is necessary to define the role of VEGF in oral squamous cell carcinoma.en
dc.description.sponsorship본 연구는 서울대학교병원 연구비(02-1996-267-0)의 지원에 의해 이루어졌음.en
dc.language.isokoen
dc.publisher대한병리학회en
dc.subjectVEGFen
dc.subjectAngiogenesisen
dc.subjectOral squamous cell carcinomaen
dc.subjectLymph node metastasisen
dc.subjectMicrovessel densityen
dc.title구강 편평세포암종에서 Vascular Endothelial Growth Factor 발현과 미세혈관 밀도en
dc.title.alternativeVEGF Expression and Microvessel Density in Oral Squamous Cell Carcinomasen
dc.typeArticleen
dc.contributor.AlternativeAuthorLim, Ji-Jun-
dc.contributor.AlternativeAuthorHong, Sam-Pyo-
dc.contributor.AlternativeAuthorLee, Jae-Il-
dc.contributor.AlternativeAuthorHong, Seong-Doo-
dc.contributor.AlternativeAuthorLim, Chang-Yun-
Appears in Collections:
Files in This Item:

Altmetrics

Item View & Download Count

  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Share