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Development of 3-D poly(trimethylenecarbonate-co-ε-caprolactone)-block-poly(p-dioxanone) scaffold for bone regeneration with high porosity using a wet electrospinning methoda wet electrospinning method
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shin, Teo Jeon | - |
dc.contributor.author | Park, Sook Young | - |
dc.contributor.author | Kim, Hyun Jeong | - |
dc.contributor.author | Lee, Hak Jun | - |
dc.contributor.author | Youk, Ji Ho | - |
dc.date.accessioned | 2011-10-17T01:04:40Z | - |
dc.date.available | 2011-10-17T01:04:40Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | Biotechnology Lett 2010;32(6):877-882 | en |
dc.identifier.issn | 0141-5492 | - |
dc.identifier.uri | https://hdl.handle.net/10371/74182 | - |
dc.description.abstract | The three dimensional (3-D) poly(trimethylenecarbonate-co-ε-caprolactone)-block-poly(p-dioxanone) scaffold was made using a wet electrospinning method and its application as a tissue engineered matrix was evaluated for bone regeneration. The scaffold was highly porous (90%) and interconnected among pores. Under scanning electron microscopy, the cells of the center of the scaffold showed healthy well attached shape even at 4 days after seeding. The osteoblastic MC3T3-E1 cells proliferated 1.2 times faster at 4 day, 1.5 times faster at 7 days after seeding as compared with the control in the scaffold (P < 0.05). The activity of alkaline phosphatase, a bone formation marker, of cells seeded in the scaffold was nearly four times faster compared to control 28 days after seeding (P < 0.05). Taken together, newly developed 3-D poly(trimethylenecarbonate-co-ε-caprolactone)-block-poly(p-dioxanone) scaffold is a promising candidate for bone regeneration. | en |
dc.description.sponsorship | The authors of this study would like to
thank the Korea Science and Engineering Foundation (KOSEF) for sponsoring this research through the SRC/ERC Program of MOST/KOSEF (R11-2005-065). | en |
dc.language.iso | en | en |
dc.publisher | Springer Verlag | en |
dc.subject | Biomaterials | en |
dc.subject | Bone regeneration | en |
dc.subject | Cell movement | en |
dc.subject | Osteoblasts | en |
dc.subject | Poly(p-dioxanone) | en |
dc.title | Development of 3-D poly(trimethylenecarbonate-co-ε-caprolactone)-block-poly(p-dioxanone) scaffold for bone regeneration with high porosity using a wet electrospinning methoda wet electrospinning method | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 신태전 | - |
dc.contributor.AlternativeAuthor | 박숙영 | - |
dc.contributor.AlternativeAuthor | 김현정 | - |
dc.contributor.AlternativeAuthor | 이학준 | - |
dc.contributor.AlternativeAuthor | 육지호 | - |
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