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Development of 3-D poly(trimethylenecarbonate-co-ε-caprolactone)-block-poly(p-dioxanone) scaffold for bone regeneration with high porosity using a wet electrospinning methoda wet electrospinning method

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dc.contributor.authorShin, Teo Jeon-
dc.contributor.authorPark, Sook Young-
dc.contributor.authorKim, Hyun Jeong-
dc.contributor.authorLee, Hak Jun-
dc.contributor.authorYouk, Ji Ho-
dc.date.accessioned2011-10-17T01:04:40Z-
dc.date.available2011-10-17T01:04:40Z-
dc.date.issued2010-
dc.identifier.citationBiotechnology Lett 2010;32(6):877-882en
dc.identifier.issn0141-5492-
dc.identifier.urihttp://hdl.handle.net/10371/74182-
dc.description.abstractThe three dimensional (3-D) poly(trimethylenecarbonate-co-ε-caprolactone)-block-poly(p-dioxanone) scaffold was made using a wet electrospinning method and its application as a tissue engineered matrix was evaluated for bone regeneration. The scaffold was highly porous (90%) and interconnected among pores. Under scanning electron microscopy, the cells of the center of the scaffold showed healthy well attached shape even at 4 days after seeding. The osteoblastic MC3T3-E1 cells proliferated 1.2 times faster at 4 day, 1.5 times faster at 7 days after seeding as compared with the control in the scaffold (P < 0.05). The activity of alkaline phosphatase, a bone formation marker, of cells seeded in the scaffold was nearly four times faster compared to control 28 days after seeding (P < 0.05). Taken together, newly developed 3-D poly(trimethylenecarbonate-co-ε-caprolactone)-block-poly(p-dioxanone) scaffold is a promising candidate for bone regeneration.en
dc.description.sponsorshipThe authors of this study would like to
thank the Korea Science and Engineering Foundation (KOSEF) for sponsoring this research through the SRC/ERC Program of MOST/KOSEF (R11-2005-065).
en
dc.language.isoenen
dc.publisherSpringer Verlagen
dc.subjectBiomaterialsen
dc.subjectBone regenerationen
dc.subjectCell movementen
dc.subjectOsteoblastsen
dc.subjectPoly(p-dioxanone)en
dc.titleDevelopment of 3-D poly(trimethylenecarbonate-co-ε-caprolactone)-block-poly(p-dioxanone) scaffold for bone regeneration with high porosity using a wet electrospinning methoda wet electrospinning methoden
dc.typeArticleen
dc.contributor.AlternativeAuthor신태전-
dc.contributor.AlternativeAuthor박숙영-
dc.contributor.AlternativeAuthor김현정-
dc.contributor.AlternativeAuthor이학준-
dc.contributor.AlternativeAuthor육지호-
Appears in Collections:
College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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