Publications
Detailed Information
The role of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinase in microcystic meningiomas
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Paek, Sun Ha | - |
dc.contributor.author | Kim, Dong Gyu | - |
dc.contributor.author | Park, Chul-Kee | - |
dc.contributor.author | Phi, Ji Hoon | - |
dc.contributor.author | Kim, Young Yim | - |
dc.contributor.author | Im, Soo Young | - |
dc.contributor.author | Kim, Jeong Eun | - |
dc.contributor.author | Park, Sung-Hye | - |
dc.contributor.author | Jung, Hee-Won | - |
dc.date.accessioned | 2011-10-17T06:59:20Z | - |
dc.date.available | 2011-10-17T06:59:20Z | - |
dc.date.issued | 2006 | - |
dc.identifier.citation | Oncol Rep 16:49-56,2006 | en |
dc.identifier.issn | 1021-335X | - |
dc.identifier.uri | https://hdl.handle.net/10371/74222 | - |
dc.description.abstract | We studied the expression of matrix metalloproteinases
(MMP) and tissue inhibitors of matrix metalloproteinase (TIMP) in microcystic meningiomas to investigate a possible underlying mechanism for the development of microcysts and of peritumoral edema, which are frequent characteristics of this rare subtype. Between October 1995 and June 2004, 10 of 19 patients who had histologically confirmed pure microcystic meningiomas were enrolled in the study. Six patients with meningothelial meningiomas, three with atypical meningiomas, and one with a transitional meningioma were included as a control group. Immunohistochemistry with paraffin blocks and real-time RT-PCR analysis for MMP-2, MMP-9, TIMP-1, TIMP-2 and vascular endothelial growth factor (VEGF) were performed using stored frozen tissues. Compared with the control group, MMP-9 was invariably and highly expressed in immunohistochemical staining of microcystic meningiomas. MMP-2, TIMP-1, TIMP-2 and VEGF were weakly expressed or not expressed in both microcystic and non-microcystic meningiomas. Realtime RT-PCR showed increased ratios of MMP-9 to TIMP-1 in microcystic meningiomas compared with the control group (55.855±106.353 vs. 1.858±2.575, respectively; p=0.00). The expression of MMP-2 (0.72±1.20 vs. 2.54±3.01, p=0.01) and TIMP-2 (1.22±1.67 vs. 1.61±1.82, p=0.02) was higher in the control group. The results suggested that the increased ratio of MMP-9 to TIMP-1 might be associated with the formation of microcysts and peritumoral edema in microcystic meningioma. | en |
dc.description.sponsorship | This study was partially supported by a grant from Seoul National University Hospital Clinical Research Institute. | en |
dc.language.iso | en | en |
dc.publisher | Spandidos Publications | en |
dc.subject | microcystic meningioma | en |
dc.subject | microcyst formation | en |
dc.subject | peritumoral edema | en |
dc.subject | MMP-9 | en |
dc.subject | TIMP-1 | en |
dc.subject | MMP-9/TIMP-1 ratio | en |
dc.title | The role of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinase in microcystic meningiomas | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 백선하 | - |
dc.contributor.AlternativeAuthor | 김동규 | - |
dc.contributor.AlternativeAuthor | 박철기 | - |
dc.contributor.AlternativeAuthor | 피지훈 | - |
dc.contributor.AlternativeAuthor | 김영임 | - |
dc.contributor.AlternativeAuthor | 임수영 | - |
dc.contributor.AlternativeAuthor | 김정은 | - |
dc.contributor.AlternativeAuthor | 박성혜 | - |
dc.contributor.AlternativeAuthor | 정희원 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.